Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. - Wikidata - awgldk - TriplyDB

Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.

Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.

http://www.wikidata.org/entity/Q36873722

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Update on genetics and diabetic retinopathy Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration Bone morphogenetic protein 2: a potential new player in the pathogenesis of diabetic retinopathy Toll-like receptor 4 in bone marrow-derived cells contributes to the progression of diabetic retinopathy.A profile of transcriptomic changes in the rd10 mouse model of retinitis pigmentosa.Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation Correlation of cytokine levels and microglial cell infiltration during retinal degeneration in RCS rats.Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia.Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism.Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4-/-Rdh8-/- Mice After Light Exposure Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration Photoreceptor Cells Produce Inflammatory Mediators That Contribute to Endothelial Cell Death in Diabetes.Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration Serum levels of lipid metabolites in age-related macular degeneration.Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model.Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina.Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation.TLR2/4 deficiency prevents oxygen-induced vascular degeneration and promotes revascularization by downregulating IL-17 in the retina.Subretinal mononuclear phagocytes induce cone segment loss via IL-1β.Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells.The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration.Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4.Photo-damage, photo-protection and age-related macular degeneration.Postprandial dietary fatty acids exert divergent inflammatory responses in retinal-pigmented epithelium cells.Friend or Foe? Resident Microglia vs Bone Marrow-Derived Microglia and Their Roles in the Retinal Degeneration.The IL-1β phenomena in neuroinflammatory diseases.Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88.Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration.CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa.Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium.Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy.

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P2860

Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.

http://www.wikidata.org/entity/Q36873722

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2013 nî lūn-bûn

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2013年论文

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2013年论文

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name

Photoreceptor proteins initiat ...... mediated by all-trans-retinal.

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Photoreceptor proteins initiat ...... mediated by all-trans-retinal.

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Photoreceptor proteins initiat ...... mediated by all-trans-retinal.

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JBC.M112.448712

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Journal of Biological Chemistry

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Photoreceptor proteins initiat ...... mediated by all-trans-retinal.

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P2093

Akiko Maeda

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Brian M Kevany

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Eric Pearlman

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Hideo Kohno

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Masaru Miyagi

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Tadao Maeda

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Yu Chen

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P2860

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

Retinopathy in mice induced by disrupted all-trans-retinal clearance

Complement factor H variant increases the risk of age-related macular degeneration

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration

Leukocyte-mediated endothelial cell injury and death in the diabetic retina

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15326-15341

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scholarly article

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10.1074/JBC.M112.448712

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21

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288

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Krzysztof Palczewski

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2013-04-09T00:00:00Z

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23572532

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Toll-like receptor

Photoreceptor protein

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3663552

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