Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)

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Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension.Pharmacokinetic interaction of riociguat with ketoconazole, clarithromycin, and midazolam Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat.

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Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)

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2016年論文

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Effects of age and sex on the ...... ulator riociguat (BAY 63-2521)

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Effects of age and sex on the ...... ulator riociguat (BAY 63-2521)

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Effects of age and sex on the ...... ulator riociguat (BAY 63-2521)

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Effects of age and sex on the ...... ulator riociguat (BAY 63-2521)

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Corina Becker

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Reiner Frey

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Soundos Saleh

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Wolfgang Mück

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P2860

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations.

Riociguat for the treatment of chronic thromboembolic pulmonary hypertension.

Riociguat for the treatment of pulmonary arterial hypertension.

An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry.

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS):

Sex differences in drug disposition.

Riociguat for the treatment of chronic thromboembolic pulmonary hypertension: a long-term extension study (CHEST-2).

Riociguat for the treatment of pulmonary arterial hypertension: a long-term extension study (PATENT-2).

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.

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10.1086/685019

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Suppl 1

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Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)

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P2860

P2860

Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)

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