An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo.
about
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.CCR2 acts as scavenger for CCL2 during monocyte chemotaxisModeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammationMonomeric structure of the cardioprotective chemokine SDF-1/CXCL12NMR Analysis of the Structure, Dynamics, and Unique Oligomerization Properties of the Chemokine CCL27Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation.Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine.SerpinB2 is critical to Th2 immunity against enteric nematode infection.IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction.Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.The level of CD147 expression correlates with cyclophilin-induced signalling and chemotaxis.Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies.Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetesCCR-2 neutralization augments murine fresh BMC activation by Staphylococcus aureus via two distinct mechanisms: at the level of ROS production and cytokine response.The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis.Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1)CCL2 nitration is a negative regulator of chemokine-mediated inflammation.Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in functionChemokines: established and novel targets in atherosclerosis.Structure-based design of decoy chemokines as a way to explore the pharmacological potential of glycosaminoglycans.Rationally evolving MCP-1/CCL2 into a decoy protein with potent anti-inflammatory activity in vivo.Buprenorphine decreases the CCL2-mediated chemotactic response of monocytesGlycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System.Novel anti-inflammatory effects of repaglinide in rodent models of inflammation.Glycosaminoglycan mimicry by COAM reduces melanoma growth through chemokine induction and function.
P2860
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P2860
An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
An engineered monomer of CCL2 ...... or chemokine activity in vivo.
@en
type
label
An engineered monomer of CCL2 ...... or chemokine activity in vivo.
@en
prefLabel
An engineered monomer of CCL2 ...... or chemokine activity in vivo.
@en
P2093
P2860
P356
P1476
An engineered monomer of CCL2 ...... for chemokine activity in vivo
@en
P2093
Adriana C Dos Santos
Amanda E I Proudfoot
David H Rodrigues
Frédéric Borlat
Matthias Mack
Maud Déruaz
Mauro M Teixeira
Pierre-Alain Vitte
Rocco Cirillo
Simona Riva
P2860
P304
P356
10.1189/JLB.0108061
P577
2008-07-28T00:00:00Z