Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells - Wikidata - awgldk - TriplyDB

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

http://www.wikidata.org/entity/Q36882529

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Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics Treating brain tumors with PDE4 inhibitors Medulloblastoma stem cells: Promising targets in medulloblastoma therapy Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs Energy metabolism in neurodevelopment and medulloblastoma In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies Significance and therapeutic value of miRNAs in embryonal neural tumors Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options Developmental origins of brain tumors Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model In vitro models of cancer stem cells and clinical applications DISP3 promotes proliferation and delays differentiation of neural progenitor cells Subgroup-specific alternative splicing in medulloblastoma Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 Genes Subtypes of medulloblastoma have distinct developmental origins Development and cancer of the cerebellum A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion.Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia In vivo Mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model.Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma.MyoD is a tumor suppressor gene in medulloblastoma.The prenatal origins of cancer Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors.Investigation of brain tissue infiltration by medulloblastoma cells in an ex vivo model β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis.Integrated analysis of miRNA and mRNA expression in childhood medulloblastoma compared with neural stem cells T-cell TGF-β signaling abrogation restricts medulloblastoma progression.Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for hedgehog-driven medulloblastoma formation.RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer.

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P2860

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

http://www.wikidata.org/entity/Q36882529

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2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Medulloblastoma can be initiat ...... cted progenitors or stem cells

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Medulloblastoma can be initiat ...... cted progenitors or stem cells

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J.CCR.2008.07.003

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Medulloblastoma can be initiat ...... cted progenitors or stem cells

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Brandon J Wainwright

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Gord Fishell

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Jessica D Kessler

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Melissa Bourboulas

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Robert J Wechsler-Reya

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Robert Machold

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Shirley L Markant

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Tammy Ellis

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Zeng-Jie Yang

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P2860

Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Cancerous stem cells can arise from pediatric brain tumors

Identification of human brain tumour initiating cells

Identification of a cancer stem cell in human brain tumors

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

Patched1 functions as a gatekeeper by promoting cell cycle progression

Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum

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135-145

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scholarly article

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10.1016/J.CCR.2008.07.003

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2

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14

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Ulrich Schüller

David H Rowitch

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2008-08-01T00:00:00Z

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23160228

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18691548

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medulloblastoma

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2538687

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