Construction of a genetic switch for inducible trans-activation of gene expression in eucaryotic cells
about
Programmed killing of human cells by means of an inducible clone of parvoviral genes encoding non-structural proteins.NF-Y controls transcription of the minute virus of mice P4 promoter through interaction with an unusual binding site.Characterization of cell lines that inducibly express the adeno-associated virus Rep proteinsThe cytotoxicity of the autonomous parvovirus minute virus of mice nonstructural proteins in FR3T3 rat cells depends on oncogene expressionA putative nucleoside triphosphate-binding domain in the nonstructural protein of B19 parvovirus is required for cytotoxicityAutonomous parvovirus DNA replication requires topoisomerase I and its activity is increased during infection.Adeno-associated virus Rep protein inhibits human immunodeficiency virus type 1 production in human cells.Restriction of porcine parvovirus replication in nonpermissive cells.Terminal regions of the NS-1 protein of the parvovirus minute virus of mice are involved in cytotoxicity and promoter trans inhibitionMutational analysis of the adeno-associated virus rep gene.Parvovirus replication in normal and transformed human cells correlates with the nuclear translocation of the early protein NS1Mutation of lysine 405 to serine in the parvovirus H-1 NS1 abolishes its functions for viral DNA replication, late promoter trans activation, and cytotoxicity.The small nonstructural protein (NS2) of the parvovirus minute virus of mice is required for efficient DNA replication and infectious virus production in a cell-type-specific mannerSelective killing of transformed rat cells by minute virus of mice does not require infectious virus production.Positive and negative regulation of the minute virus of mice P38 promoter.Susceptibility of human cells to killing by the parvoviruses H-1 and minute virus of mice correlates with viral transcription.Cloning of minute virus of mice cDNAs and preliminary analysis of individual viral proteins expressed in murine cells.Transformation of human cells by oncogenic viruses supports permissiveness for parvovirus H-1 propagation.Both excision and replication of cloned autonomous parvovirus DNA require the NS1 (rep) protein.Partial reversion of conditional transformation correlates with a decrease in the sensitivity of rat cells to killing by the parvovirus minute virus of mice but not in their capacity for virus production: effect of a temperature-sensitive v-src oncoA GC-box motif upstream of the B19 parvovirus unique promoter is important for in vitro transcription.Transformation of human fibroblasts by ionizing radiation, a chemical carcinogen, or simian virus 40 correlates with an increase in susceptibility to the autonomous parvoviruses H-1 virus and minute virus of mice.Generation and characterization of a temperature-sensitive mutation in the NS-1 gene of the autonomous parvovirus minute virus of mice.The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells.Efficient transactivation of the minute virus of mice P38 promoter requires upstream binding of NS1.Characterization of the minute virus of mice P38 core promoter elements.Influence of adeno-associated virus on adherence and growth properties of normal cells.The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.The infectivity and lytic activity of minute virus of mice wild-type and derived vector particles are strikingly different.
P2860
Q33921508-D4DCF760-F3EB-4218-8BC6-2F97A7395FC4Q35829395-BE9FC124-40CE-4510-AB9B-8A5943730591Q36624044-1C2071F3-CAE8-4307-A3D4-F404B1B8AFACQ36636125-BE3BAEB4-A0EE-4E7E-8950-5CFB79C8B73EQ36638366-D89D303A-D732-4B1F-AF70-76B99CBE668AQ36683177-C3D97673-4A32-47C3-BC4E-1F982E97C707Q36688082-B0AEBAE0-81D7-46D2-BE46-F3914E739BCEQ36690376-F49EFEBC-D65C-47C9-A865-C962C4B86592Q36701980-02007029-2112-44C5-AB77-AE7D79B7D86FQ36702316-617FDD15-9074-46B2-9AA4-DD503865BFB4Q36780288-0CB5051F-5F32-4A18-ACD1-3C18D43A5A65Q36783577-52759548-1BF0-4A06-85B6-4AD4B0A1C9C5Q36796255-019D5D4F-BA0D-4050-A544-808EBD92FB3FQ36799999-9DF9D1F6-0ABB-45CF-8E19-7FD861A8E42AQ36805522-F2C92621-ADC4-4AC8-BBB3-2FFB6F9CA2F5Q36806656-A0F252AD-7E6D-4ABD-BD04-E26874B4777BQ36812647-E79569EE-AB15-4D16-BC7A-338993071D95Q36827436-270B6410-BF21-4589-952F-4094AE044E66Q36831003-DDBA0FB2-0DB6-4198-AF9F-2D73C243A72BQ36831670-DCF8E3A7-5E3C-4FD9-97B3-24613A5EBD3CQ36831680-C5D26D21-7D3C-4738-A1AB-7F9EA5600A4EQ36866826-27746130-CD1D-45B9-A94B-5AD4145A554FQ36878422-55D2F3D2-1248-4225-A828-CD1185412374Q36878960-08E464CF-C78C-4511-A0E0-091623D9FAEBQ39873340-91A8BD18-60CF-4FCF-A47C-F964B6045505Q39880841-52D23A25-F75F-49D5-AC86-54D0206EB59CQ40063899-2655F3E4-F90D-4494-997C-C002A8C66A3DQ40109360-B3122436-23FC-4331-AB75-753E030371D1Q40481123-1C0A7F63-DA8E-45D1-B8E5-BD8F58439F24
P2860
Construction of a genetic switch for inducible trans-activation of gene expression in eucaryotic cells
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Construction of a genetic swit ...... expression in eucaryotic cells
@en
type
label
Construction of a genetic swit ...... expression in eucaryotic cells
@en
prefLabel
Construction of a genetic swit ...... expression in eucaryotic cells
@en
P2860
P1433
P1476
Construction of a genetic swit ...... expression in eucaryotic cells
@en
P2093
P2860
P304
P407
P577
1987-05-01T00:00:00Z