TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. - Wikidata - awgldk - TriplyDB

TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.

TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.

http://www.wikidata.org/entity/Q36893657

about

FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity Ubiquitin-dependent regulation of Foxp3 and Treg function Treg functional stability and its responsiveness to the microenvironment Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function FOXP3+ regulatory T cells and their functional regulation Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy Foxp3 protein stability is regulated by cyclin-dependent kinase 2 Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells Ubiquitous points of control over regulatory T cells.Rapid temporal control of Foxp3 protein degradation by sirtuin-1.All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus.Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function.Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.Epigenetic enzymes are the therapeutic targets for CD4(+)CD25(+/high)Foxp3(+) regulatory T cells Endurance exercise diverts the balance between Th17 cells and regulatory T cells Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells.IL-6 promotes cardiac graft rejection mediated by CD4+ cells.Histone/protein deacetylases and T-cell immune responses Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions Regulatory T cells modulate staphylococcal enterotoxin B-induced effector T-cell activation and acceleration of colitis.Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications.CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance.The T(reg)/Th17 cell balance: a new paradigm for autoimmunity.Epigenetic mechanisms of regulation of Foxp3 expression.Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells.Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers.Protective effect of cytosolic phospholipase A2 inhibition against inflammation and degeneration by promoting regulatory T cells in rats with experimental autoimmune encephalomyelitis.Treating arthritis by immunomodulation: is there a role for regulatory T cells?Harnessing regulatory T cells for the therapy of lupus and other autoimmune diseases.Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function.Physiologic control of the functional status of Foxp3+ regulatory T cells.The dual role of the X-linked FoxP3 gene in human cancers

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P2860

TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.

http://www.wikidata.org/entity/Q36893657

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

TGF-beta and IL-6 signals modu ...... occupancy by acetylated FOXP3.

@en

type

label

TGF-beta and IL-6 signals modu ...... occupancy by acetylated FOXP3.

@en

prefLabel

TGF-beta and IL-6 signals modu ...... occupancy by acetylated FOXP3.

@en

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PNAS.0806726105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

TGF-beta and IL-6 signals modu ...... occupancy by acetylated FOXP3

@en

P2093

Arabinda Samanta

http://www.w3.org/2001/XMLSchema#string

Bin Li

http://www.w3.org/2001/XMLSchema#string

Geng Zhang

http://www.w3.org/2001/XMLSchema#string

Kathryn Bembas

http://www.w3.org/2001/XMLSchema#string

Makoto Katsumata

http://www.w3.org/2001/XMLSchema#string

Mark I Greene

http://www.w3.org/2001/XMLSchema#string

Sandra J Saouaf

http://www.w3.org/2001/XMLSchema#string

Wayne W Hancock

http://www.w3.org/2001/XMLSchema#string

Xiaomin Song

http://www.w3.org/2001/XMLSchema#string

Yuan Shen

http://www.w3.org/2001/XMLSchema#string

P2860

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Control of regulatory T cell development by the transcription factor Foxp3

Transforming growth factor-beta induces development of the T(H)17 lineage

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

Regulatory T cells and immune tolerance

P304

14023-14027

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10.1073/PNAS.0806726105

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37

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105

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23245338

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18779564

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2544572

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