The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.
about
trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificitiesNeurotrophins: roles in neuronal development and functionNeurotrophin-regulated signalling pathwaysThe signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiationHigh resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptorsEnhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATPDifferential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesionTwo functional forms of vascular endothelial growth factor receptor-2/Flk-1 mRNA are expressed in normal rat retinaEarly evolutionary origin of the neurotrophin receptor family.Visualization of the dynamics of synaptic vesicle and plasma membrane proteins in living axons.Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors.TrkA cross-linking mimics neuronal responses to nerve growth factorTargeted delivery of TrkB receptor to phrenic motoneurons enhances functional recovery of rhythmic phrenic activity after cervical spinal hemisection.Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell lineNovel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms.An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.Nerve growth factor induces neuron-like differentiation of an insulin-secreting pancreatic beta cell line.Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.Pancreatic beta cells synthesize and secrete nerve growth factorChimeric tumor necrosis factor-TrkA receptors reveal that ligand-dependent activation of the TrkA tyrosine kinase is sufficient for differentiation and survival of PC12 cellsExpression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones.The coming of age of axonal neurotrophin signaling endosomes.An immunoglobulin-like domain determines the specificity of neurotrophin receptors.Is it possible to improve neurodevelopmental abnormalities in Down syndrome?Molecular mechanisms of cognitive impairment in iron deficiency: alterations in brain-derived neurotrophic factor and insulin-like growth factor expression and function in the central nervous system.Structural and functional properties of the TRK family of neurotrophin receptors.Tyrosine 785 is a major determinant of Trk--substrate interaction.TrkA mediates the nerve growth factor-induced intracellular calcium accumulation.Dexamethasone regulates the expression of neuronal properties of a rat insulinoma cell line.Similarities and discrepancies in the signaling pathway for nerve growth factor in an insulin producing cell line and a neural crest-derived cell line.Nerve growth factor signaling in caveolae-like domains at the plasma membrane.Ectopic expression of TrKA in the adult rat basal ganglia induces both nerve growth factor-dependent and -independent neuronal responses.Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor.TrkB variants with deletions in the leucine-rich motifs of the extracellular domain.Ectopic trkA expression mediates a NGF survival response in NGF-independent sensory neurons but not in parasympathetic neurons.Exogenous NT-3 and NGF differentially modulate PACAP expression in adult sensory neurons, suggesting distinct roles in injury and inflammation.Prolonged recycling of internalized neurotrophins in the nerve terminal.Regulation of NGF-family ligands and receptors in adulthood and senescence: correlation to degenerative and regenerative changes in cutaneous innervation.Signalling organelle for retrograde axonal transport of internalized neurotrophins from the nerve terminal.All-trans retinoic acid stimulates and maintains neurite outgrowth in nerve growth factor-supported developing chick embryonic sympathetic neurons.
P2860
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P2860
The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
The rat trk protooncogene prod ...... nerve growth factor receptor.
@en
type
label
The rat trk protooncogene prod ...... nerve growth factor receptor.
@en
prefLabel
The rat trk protooncogene prod ...... nerve growth factor receptor.
@en
P2093
P2860
P356
P1476
The rat trk protooncogene prod ...... nerve growth factor receptor.
@en
P2093
A A Welcher
C C Drinkwater
E M Shooter
S O Meakin
P2860
P304
P356
10.1073/PNAS.89.6.2374
P407
P577
1992-03-01T00:00:00Z