Universal allosteric mechanism for Gα activation by GPCRs.
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Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network ModelAutosomal Dominant Hypocalcemia (Hypoparathyroidism) Types 1 and 2Residue Geometry Networks: A Rigidity-Based Approach to the Amino Acid Network and Evolutionary Rate AnalysisA Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated ReceptorVibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.AlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription RegulatorsMini-G proteins: Novel tools for studying GPCRs in their active conformation.The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling.Nanobodies to Study G Protein-Coupled Receptor Structure and Function.Identifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species ConservationAllosteric switch regulates protein-protein binding through collective motion.Dynamic Coupling and Allosteric Networks in the α Subunit of Heterotrimeric G Proteins.Probing Gαi1 protein activation at single-amino acid resolution.Identification of a G-Protein Subunit-α11 Gain-of-Function Mutation, Val340Met, in a Family With Autosomal Dominant Hypocalcemia Type 2 (ADH2)Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding.A G-protein Subunit-α11 Loss-of-Function Mutation, Thr54Met, Causes Familial Hypocalciuric Hypercalcemia Type 2 (FHH2)Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions.The Molecular Mechanism of P2Y1 Receptor ActivationDiverse activation pathways in class A GPCRs converge near the G-protein-coupling regionRic-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein ActivationKnockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.Exploiting sequence and stability information for directing nanobody stability engineering.Tubby family proteins are adapters for ciliary trafficking of integral membrane proteinsSingle-molecule analysis of ligand efficacy in β2AR-G-protein activation.Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.Coagulation and non-coagulation effects of thrombin.The Histamine H3 Receptor: Structure, Pharmacology, and Function.Mechanistic insights into GPCR-G protein interactions.Structure of the adenosine A(2A) receptor bound to an engineered G protein.Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation.Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.Conformational and Thermodynamic Landscape of GPCR Activation from Theory and Computation.Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation.Pharmacogenomics of GPCR Drug Targets.Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas.Activation processes in ligand-activated G protein-coupled receptors: A case study of the adenosine A2A receptor.
P2860
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P2860
Universal allosteric mechanism for Gα activation by GPCRs.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Universal allosteric mechanism for Gα activation by GPCRs.
@en
type
label
Universal allosteric mechanism for Gα activation by GPCRs.
@en
prefLabel
Universal allosteric mechanism for Gα activation by GPCRs.
@en
P2093
P2860
P50
P356
P1433
P1476
Universal allosteric mechanism for Gα activation by GPCRs.
@en
P2093
A J Venkatakrishnan
Charles N J Ravarani
Christopher G Tate
Melis Kayikci
Tilman Flock
P2860
P2888
P304
P356
10.1038/NATURE14663
P407
P577
2015-07-06T00:00:00Z