Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene.
about
Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearanceThe importance of the granulocyte-colony stimulating factor in oncologyG-CSF and GM-CSF in NeutropeniaEngineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AMLG-CSFR ubiquitination critically regulates myeloid cell survival and proliferation.From famine to feast: sending out the clones.Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis.Investigation and analysis of single nucleotide polymorphisms in Janus kinase/signal transducer and activator of transcription genes with leukemia.Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptorMutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activityLeukemia in severe congenital neutropenia: defective proteolysis suggests new pathways to malignancy and opportunities for therapy.A truncation mutant of Csf3r cooperates with PML-RARĪ± to induce acute myeloid leukemia in mice.STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapyDistinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesisAndrogen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice.Cross-regulation of JAK and Src kinases.Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment.Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.Role of the proteasome in modulating native G-CSFR expression.Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor.Hematopoietic stem cell transplantation for severe congenital neutropenia.Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy.A Truncated Granulocyte Colony-stimulating Factor Receptor (G-CSFR) Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: IMPLICATION FOR UNDERSTANDING CSF3R GENE MUTATIONS IN SEVERE CONGENITAL NEUTROPENIA.Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies.Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition.Severe congenital neutropenias.Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors.Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations.Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia.G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1.The carboxyl-terminal domain of the granulocyte colony-stimulating factor receptor uncouples ribosomal biogenesis from cell cycle progression in differentiating 32D myeloid cells.Enhanced MAPK signaling is essential for CSF3R-induced leukemia.G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.Severe congenital neutropenia and chronic neutrophilic leukemia: an intriguing molecular connection unveiled by oncogenic mutations in CSF3R.Umbilical cord blood stem cell transplantation from unrelated HLA-matched donor in an infant with severe congenital neutropenia.
P2860
Q24795355-6DAFEFA1-5421-40D6-91C7-1222646471BAQ26770908-5B3FAAC5-D1D9-434A-B7ED-07A6F20D1618Q26800954-8FF79D7F-1CF3-4B09-8741-30ECBFD90BF1Q26828777-E698D7D6-ABDE-40DC-A95C-13BC8BDBF350Q30155926-823E7455-05BE-4052-BBAC-5CE5FADF204DQ33344491-96D08254-A574-4D48-9BDA-D7B7008C9112Q33377020-DC3191E9-3738-4481-9C93-4CE8E17F54B7Q33758311-67B88968-B90B-4835-8A2C-4E23FD25E489Q33780538-CCE86051-FE14-4683-BBEE-9776AD8F158BQ34085965-DE301F64-77A2-4C40-A684-8F643DE96246Q35080710-2D7AC150-EADF-4CEA-B4B9-A65DF9F4AEEDQ35134457-3D6A88AA-47B6-4FC6-8CCC-8435AEFBF045Q35553861-D8340F90-D76E-42BB-BE65-7F3B36AB4BC5Q35564931-9958A0E1-9019-44E3-AED8-1BF01B22C428Q35848810-522DA0CA-D06E-49F5-91D3-4219D37F5627Q35849723-C8EFE5FB-71F2-418D-A062-66D500F7A7F5Q35989473-23F186D6-F6D9-4623-A42D-D499B6E50D22Q36141626-4468ADD7-AEC3-4E9F-BBDF-16A4DF5E5902Q36355602-B4C22324-153F-463E-BB56-F5DE4DED70CCQ36360695-BE5C2929-D067-4227-A772-56EF2931DF4CQ36375198-74AADC0D-F840-4A5E-AEE7-1686BCC6735DQ36470463-E0485780-7EDA-4259-B250-0C5ED1F57A9CQ36915628-CAC6BA3C-E177-45E2-A96B-9D415E420247Q37273091-74080316-E23D-414E-9175-811F3ACDA462Q37955726-354C265E-5DC1-4DCB-9A1C-355ADA47C19AQ38211431-F734355C-1954-4940-BEDC-C54B249866AFQ38722029-0F805CD2-4A1B-47D6-B65D-8CBFCD47EC20Q38993081-42FC8A85-983B-43BA-A0DC-E51738DB68DCQ39068979-AD96FEB6-43C7-4FB4-9AFB-89036C02A0A8Q39359222-85A2C10B-3FBE-48AB-ACB1-2C73AE83D163Q40215423-1D60255A-1608-4DFA-A515-AE6A319E18DFQ40229517-57A8A739-8F81-4483-BC74-E703014F487BQ40311738-76BB2CA9-2758-47E3-AD29-243F76A7E268Q40352398-E5E50CD8-73DE-4405-A74A-7ABD63893641Q40395394-AB2AEAF5-749A-4078-9E6A-AC17CB55C08BQ40775108-9387C3BB-8A7B-4762-90DE-7A6E560AA1F8Q41190362-A8C45454-493B-4AC1-B4F1-ED784BE1A176Q41788910-6DC18FED-0443-4620-86D6-11A544894198Q42958779-0EE91326-5E1C-4BA8-B2D4-C12601BDB262Q44788989-A457CC84-E5E7-403E-BD70-3B9909477A8B
P2860
Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene.
description
1999 nĆ® lÅ«n-bĆ»n
@nan
1999幓ć®č«ę
@ja
1999幓č«ę
@yue
1999幓č«ę
@zh-hant
1999幓č«ę
@zh-hk
1999幓č«ę
@zh-mo
1999幓č«ę
@zh-tw
1999幓č®ŗę
@wuu
1999幓č®ŗę
@zh
1999幓č®ŗę
@zh-cn
name
Sustained receptor activation ...... on in the G-CSF receptor gene.
@en
type
label
Sustained receptor activation ...... on in the G-CSF receptor gene.
@en
prefLabel
Sustained receptor activation ...... on in the G-CSF receptor gene.
@en
P2093
P2860
P356
P1476
Sustained receptor activation ...... ion in the G-CSF receptor gene
@en
P2093
C Antonissen
M H Hermans
R E Ploemacher
P2860
P304
P356
10.1084/JEM.189.4.683
P407
P577
1999-02-01T00:00:00Z