Translational research in medication development for nicotine dependence. - Wikidata - awgldk - TriplyDB

Translational research in medication development for nicotine dependence.

Translational research in medication development for nicotine dependence.

http://www.wikidata.org/entity/Q36906670

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Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation Pharmacotherapy of amphetamine-type stimulant dependence: an update Effects of experimental negative affect manipulations on ad libitum smoking: a meta-analysis The neurobiology of emotion-cognition interactions: fundamental questions and strategies for future research New mechanisms and perspectives in nicotine withdrawal Emerging drugs for the treatment of tobacco dependence: 2014 update Larval zebrafish model for FDA-approved drug repositioning for tobacco dependence treatment ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice.Using the threat probability task to assess anxiety and fear during uncertain and certain threat.The effects of galantamine on nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6 mice.Varenicline improves mood and cognition during smoking abstinence.Progressive and lasting amplification of accumbal nicotine-seeking neural signals Neural bases of pharmacological treatment of nicotine dependence - insights from functional brain imaging: a systematic review.Working memory deficits predict short-term smoking resumption following brief abstinence.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.Nicotine vaccines: will smokers take a shot at quitting?Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors Mouse model predicts effects of smoking and varenicline on event-related potentials in humans.Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats.Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner.A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction.Translational Research on Nicotine Dependence.Cognitive deficits specific to depression-prone smokers during abstinence.Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal.Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers Early human screening of medications to treat drug addiction: novel paradigms and the relevance of pharmacogenetics.Translational research: current status, challenges and future strategies.Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.Neurobiological impact of nicotinic acetylcholine receptor agonists: an activation likelihood estimation meta-analysis of pharmacologic neuroimaging studies The effects of extended pre-quit varenicline treatment on smoking behavior and short-term abstinence: a randomized clinical trial Tobacco dependence and withdrawal: science base, challenges and opportunities for pharmacotherapy.Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist Resting state functional connectivity in addiction: Lessons learned and a road ahead Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats Does Extended Pre Quit Bupropion Aid in Extinguishing Smoking Behavior?Fostering multiple healthy lifestyle behaviors for primary prevention of cancer.Pharmacological Options for Smoking Cessation in Heavy-Drinking Smokers Neural substrates of abstinence-induced cigarette cravings in chronic smokers.Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice.

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P2860

Translational research in medication development for nicotine dependence.

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Nature Reviews Drug Discovery

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Translational research in medication development for nicotine dependence.

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Kenneth A Perkins

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Mark G LeSage

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Neal L Benowitz

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Stephanie S O'Malley

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Steven J Siegel

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William A Corrigall

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P2860

Intracranial self-stimulation thresholds: a model for the hedonic effects of drugs of abuse.

The discriminative stimulus and reinforcing effects of nicotine in humans following nicotine pretreatment.

Baclofen antagonizes intravenous self-administration of nicotine in mice and rats.

SR141716, a central cannabinoid (CB(1)) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats.

Impaired serum cortisol stress response is a predictor of early relapse.

The behavioral economics of cigarette smoking: The concurrent presence of a substitute and an independent reinforcer.

Nicotine gum as a substitute for cigarettes: a behavioral economic analysis.

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10.1038/NRD2361

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