Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease.
about
Aptamers: A New Technological Platform in Cancer ImmunotherapyEmerging roles of Egr2 and Egr3 in the control of systemic autoimmunityEGR-2 is not required for in vivo CD4 T cell mediated immune responses.A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis.Early growth response gene-2 (Egr-2) regulates the development of B and T cells.TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responsesRegulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1EGR2 is critical for peripheral naïve T-cell differentiation and the T-cell response to influenza.The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses.Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production.CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy.Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells.Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes.Polar opposites: Erk direction of CD4 T cell subsets.The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells.Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2.Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-βEarly growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses.Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis).Genetic and biochemical regulation of CD4 T cell effector differentiation: insights from examination of T cell clonal anergy.Molecular mechanisms of T-cell tolerance.T-cell tolerance in cancer.mTORC1 signaling and IL-17 expression: Defining pathways and possible therapeutic targets.Therapeutic potential of regulatory cytokines that target B cells.The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential.The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs.Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation.Anti-CD44 induces apoptosis in T lymphoma via mitochondrial depolarization.Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.Early Growth Response Genes 2 and 3 Regulate the Expression of Bcl6 and Differentiation of T Follicular Helper Cells.Early growth response 2 and Egr3 are unique regulators in immune systemTh17 differentiation is the default program for DPP2-deficient T-cell differentiation.Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.Regulatory T cell-mediated control of autoantibody-induced inflammation.Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism.Egr2 and Egr3 are the unique regulators for systemic autoimmunity.
P2860
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P2860
Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Early growth response gene 2 ( ...... lupuslike autoimmune disease.
@en
type
label
Early growth response gene 2 ( ...... lupuslike autoimmune disease.
@en
prefLabel
Early growth response gene 2 ( ...... lupuslike autoimmune disease.
@en
P2093
P2860
P356
P1476
Early growth response gene 2 ( ...... lupuslike autoimmune disease.
@en
P2093
Alistair L J Symonds
David C Wraith
Dimitris Kioussis
Joanne E Martin
P2860
P304
P356
10.1084/JEM.20080187
P407
P577
2008-09-08T00:00:00Z