TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
about
An emerging role for TOR signaling in mammalian tissue and stem cell physiologyChanges in Regenerative Capacity through LifespanAutophagy in stem cells.To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemmaReactive oxygen species in cancer stem cellsRedox regulation of stem/progenitor cells and bone marrow nicheMitophagy in hematopoietic stem cells: the case for explorationReactive oxygen species adversely impacts bone marrow microenvironment in diabetesNutrient-sensing pathways and metabolic regulation in stem cellsGSK-3 as potential target for therapeutic intervention in cancerTherapeutic Strategies for Oxidative Stress-Related Cardiovascular Diseases: Removal of Excess Reactive Oxygen Species in Adult Stem CellsRole of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cellsRapalogs and mTOR inhibitors as anti-aging therapeuticsChallenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Plzf regulates germline progenitor self-renewal by opposing mTORC1Redox homeostasis: the linchpin in stem cell self-renewal and differentiationGene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte developmentSestrin as a feedback inhibitor of TOR that prevents age-related pathologiesROS function in redox signaling and oxidative stressmTOR signaling at a glanceTransformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation processNonthermal atmospheric pressure plasma enhances mouse limb bud survival, growth, and elongationMEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in miceDiabetes mellitus induces bone marrow microangiopathy.Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cellsTotal body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.Autophagy is a signature of a signaling network that maintains hematopoietic stem cellsNovel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia.mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signalingAKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.Metabolic requirements for the maintenance of self-renewing stem cells.Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cellsMitochondria are required for pro-ageing features of the senescent phenotype.Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cellsRegulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression.Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations.Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cellsStem cell aging: mechanisms, regulators and therapeutic opportunities.
P2860
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P2860
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
TSC-mTOR maintains quiescence ...... is and reactive oxygen species
@en
type
label
TSC-mTOR maintains quiescence ...... is and reactive oxygen species
@en
prefLabel
TSC-mTOR maintains quiescence ...... is and reactive oxygen species
@en
P2093
P2860
P356
P1476
TSC-mTOR maintains quiescence ...... is and reactive oxygen species
@en
P2093
Chong Chen
Kun-Liang Guan
Runhua Liu
Tsuneo Ikenoue
P2860
P304
P356
10.1084/JEM.20081297
P407
P577
2008-09-22T00:00:00Z