Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
about
Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cellsProlyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteinsProlyl isomerase Pin1 in cancerThe prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancerIn cortical neurons HDAC3 activity suppresses RD4-dependent SMRT exportRegulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.Membrane permeable cyclic peptidyl inhibitors against human Peptidylprolyl Isomerase Pin1.The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer.Phosphorylation stabilizes Nanog by promoting its interaction with Pin1The SMRT coregulator enhances growth of estrogen receptor-α-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis.Alpha-actinin 4 and tumorigenesis of breast cancer.The roles of peptidyl-proline isomerases in gene regulation.Nuclear receptor corepressor complexes in cancer: mechanism, function and regulationDeath-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular functionInhibition of Nek2 by small molecules affects proteasome activity.Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancerPeptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α.Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinantWnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor proteinElevated nuclear expression of the SMRT corepressor in breast cancer is associated with earlier tumor recurrenceEmerging roles of the corepressors NCoR1 and SMRT in homeostasis.β-Transducin repeat-containing protein 1 (β-TrCP1)-mediated silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) protein degradation promotes tumor necrosis factor α (TNFα)-induced inflammatory gene expression.New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoRPin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation.Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process.G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation.Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease.The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target.PIN1 in breast development and cancer: a clinical perspective.Neighboring phosphoSer-Pro motifs in the undefined domain of IRAK1 impart bivalent advantage for Pin1 binding.Protein kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells.Prolyl isomerase Pin1: a promoter of cancer and a target for therapy
P2860
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P2860
Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
@en
type
label
Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
@en
prefLabel
Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
@en
P2093
P2860
P356
P1476
Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
@en
P2093
Anthony R Means
Hung-Ying Kao
Kristopher J Stanya
P2860
P356
10.1083/JCB.200806172
P407
P577
2008-10-01T00:00:00Z