Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
about
Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethalityState of the science: an update on renal cell carcinomaTargeting Cancer Metabolism - Revisiting the Warburg EffectsNovel drugs that target the metabolic reprogramming in renal cell cancerThe sweet trap in tumors: aerobic glycolysis and potential targets for therapyNovel therapeutic targets of tumor metabolismSLC transporters as therapeutic targets: emerging opportunitiesMetabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentialityBrowning of white adipose tissue uncouples glucose uptake from insulin signalingGlucose is a key driver for GLUT1-mediated nanoparticles internalization in breast cancer cellsGlucose transport: meeting the metabolic demands of cancer, and applications in glioblastoma treatmentA DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effectTRAF3 deficiency promotes metabolic reprogramming in B cellsSynthetic lethality: emerging targets and opportunities in melanoma.Current views on cell metabolism in SDHx-related pheochromocytoma and paragangliomaTargeting MYC Dependence by Metabolic Inhibitors in CancerIsoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding.Concise Review: Cell Surface N-Linked Glycoproteins as Potential Stem Cell Markers and Drug TargetsN-myc downstream-regulated gene 2 expression is associated with glucose transport and correlated with prognosis in breast carcinoma.Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway.Chromatin-regulating proteins as targets for cancer therapy.Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets.Evolutionary dynamics of carcinogenesis and why targeted therapy does not work.Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro studyMolecular radiobiology: the state of the artAerobic glycolysis: a novel target in kidney cancer.Functional architecture of MFS D-glucose transporters.Down regulation of Wnt signaling mitigates hypoxia-induced chemoresistance in human osteosarcoma cells.Collateral Lethality: A new therapeutic strategy in oncologyAntitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma.The contributions of HIF-target genes to tumor growth in RCC.The Warburg effect: evolving interpretations of an established conceptRapid analysis of glycolytic and oxidative substrate flux of cancer cells in a microplateInhibition of an NAD⁺ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells.In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.Approaches to identifying synthetic lethal interactions in cancer.MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolismTargeting glucose metabolism for cancer therapy.
P2860
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P2860
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Targeting GLUT1 and the Warbur ...... y chemical synthetic lethality
@en
type
label
Targeting GLUT1 and the Warbur ...... y chemical synthetic lethality
@en
prefLabel
Targeting GLUT1 and the Warbur ...... y chemical synthetic lethality
@en
P2093
P2860
P1476
Targeting GLUT1 and the Warbur ...... y chemical synthetic lethality
@en
P2093
Alice Banh
Amato J Giaccia
David E Solow-Cordero
Denise A Chan
Donna M Bouley
Edward E Graves
Edwin W Lai
Gloria E Reynolds
Jack U Flanagan
P2860
P304
P356
10.1126/SCITRANSLMED.3002394
P407
P577
2011-08-01T00:00:00Z