Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease.
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Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanismsTherapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorderDefining the role of the Bcl-2 family proteins in Huntington's diseaseMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases?Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's diseaseNonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.Exercise is not beneficial and may accelerate symptom onset in a mouse model of Huntington's diseaseAltered dopamine and serotonin metabolism in motorically asymptomatic R6/2 miceSmall-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's diseaseElectroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.Impaired adaptive cellular responses to oxidative stress and the pathogenesis of Alzheimer's diseaseIron accumulates in Huntington's disease neurons: protection by deferoxamineLocalized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain.Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease.Neuroprotective potential of escitalopram against behavioral, mitochondrial and oxidative dysfunction induced by 3-nitropropionic acid.Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging.Evaluation of a cone beam computed tomography geometry for image guided small animal irradiationTreatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise.Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse modelHuntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality.Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin.Extensive changes in DNA methylation are associated with expression of mutant huntingtin.Targeting sirtuin-1 in Huntington's disease: rationale and current status.Targeting H3K4 trimethylation in Huntington diseasePatterns of serotonergic antidepressant usage in prodromal Huntington diseaseA small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.From neurotransmitters to neurotrophic factors to neurogenesis.Functional interrogation of adult hypothalamic neurogenesis with focal radiological inhibition.Preventing late-life depression: a clinical update.Molecular mechanisms and potential therapeutical targets in Huntington's disease.A review: treatment of Alzheimer's disease discovered in repurposed agents.Antidepressants for neuro-regeneration: from depression to Alzheimer's disease.Neuroprotective effects of psychotropic drugs in Huntington's diseasePotential therapeutic targets in polyglutamine-mediated diseases.From pathways to targets: understanding the mechanisms behind polyglutamine disease.Sertraline increases the survival of retinoic acid induced neuronal cells but not glial cells from human mesenchymal stem cells.
P2860
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P2860
Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Sertraline slows disease progr ...... model of Huntington's disease.
@en
type
label
Sertraline slows disease progr ...... model of Huntington's disease.
@en
prefLabel
Sertraline slows disease progr ...... model of Huntington's disease.
@en
P2093
P2860
P1476
Sertraline slows disease progr ...... model of Huntington's disease.
@en
P2093
Bruce Ladenheim
Erik Tryggestad
Jean Lud Cadet
Naoki Masuda
Wenzhen Duan
P2860
P304
P356
10.1016/J.NBD.2008.01.015
P577
2008-03-10T00:00:00Z