Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1). - Wikidata - awgldk - TriplyDB

Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1).

Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1).

http://www.wikidata.org/entity/Q36934640

about

Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus Interleukin-27: balancing protective and pathological immunity Interleukin-27 in T cell immunity Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus.WSX1 expression in tumors induces immune tolerance via suppression of effector immune cells.IL-27 Regulates IL-18 binding protein in skin resident cells TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses IL-27-induced modulation of autoimmunity and its therapeutic potential.The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses.An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation.The dysregulation of cytokine networks in systemic lupus erythematosus.Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination.Interleukin 27: a double-edged sword for offense and defense.Therapeutic potential of IL-27 in systemic lupus erythematosus.Regulatory T-cell-associated cytokines in systemic lupus erythematosus.IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice.Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient.Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A.Overexpression of Epstein-Barr virus-induced gene 3 protein (EBI3) in MRL/lpr mice suppresses their lupus nephritis by activating regulatory T cells.Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin.Decreased serum interleukin 27 in Brazilian systemic lupus erythematosus patients.IL-27 is elevated in acute lung injury and mediates inflammation.T cell-specific overexpression of interleukin-27 receptor α subunit (WSX-1) prevents spontaneous skin inflammation in MRL/lpr mice.Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice.

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Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1).

http://www.wikidata.org/entity/Q36934640

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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Amelioration of human lupus-li ...... kin 27 receptor alpha (WSX-1).

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Amelioration of human lupus-li ...... kin 27 receptor alpha (WSX-1).

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Amelioration of human lupus-li ...... kin 27 receptor alpha (WSX-1).

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ARD.2007.077537

P1433

Annals of the Rheumatic Diseases

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Amelioration of human lupus-li ...... kin 27 receptor alpha (WSX-1).

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P2093

Akahoshi M

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Hamano S

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Takeda A

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P2860

Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

Cloning and characterization of a novel class I cytokine receptor

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.

Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease.

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.

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