Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.
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GMFβ controls branched actin content and lamellipodial retraction in fibroblasts.PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.Macropinosomes are Key Players in Early Shigella Invasion and Vacuolar Escape in Epithelial CellsUbl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branchingPerinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.Actin kinetics shapes cortical network structure and mechanics.Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex.Structural basis for regulation of Arp2/3 complex by GMFControl of polarized assembly of actin filaments in cell motilityActin-Related Protein 2 (ARP2) and Virus-Induced Filopodia Facilitate Human Respiratory Syncytial Virus SpreadRole and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complexMacrophages redirect phagocytosis by non-professional phagocytes and influence inflammation.CPI motif interaction is necessary for capping protein function in cells.Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells.ARP2/3-mediated junction-associated lamellipodia control VE-cadherin-based cell junction dynamics and maintain monolayer integrityDip1 defines a class of Arp2/3 complex activators that function without preformed actin filamentsHomeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers.Interactions with actin monomers, actin filaments, and Arp2/3 complex define the roles of WASP family proteins and cortactin in coordinately regulating branched actin networksFunctional analysis of Girardia tigrina transcriptome seeds pipeline for anthelmintic target discovery.Open source software for quantification of cell migration, protrusions, and fluorescence intensities.Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.The ARP 2/3 complex mediates endothelial barrier function and recovery.Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration.Actin cytoskeleton regulator Arp2/3 complex is required for DLL1 activating Notch1 signaling to maintain the stem cell phenotype of glioma initiating cells.Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets.Actin is required for IFT regulation in Chlamydomonas reinhardtiiBrain proteomics identifies potential simvastatin targets in acute phase of stroke in a rat embolic model.Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs.Protrusive and Contractile Forces of Spreading Human Neutrophils.De novo actin polymerization is required for model Hirano body formation in Dictyostelium.Acquisition of the dorsal structures in chordate amphioxus.Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASPThree-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation.Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells.Extracellular motility and cell-to-cell transmission of enterohemorrhagic E. coli is driven by EspFU-mediated actin assembly.KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.The lens actin filament cytoskeleton: Diverse structures for complex functions.Actin nucleation by WH2 domains at the autophagosomeCell matrix adhesions in cancer: The proteins that form the glue.
P2860
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P2860
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Small molecules CK-666 and CK- ...... ivating conformational change.
@en
type
label
Small molecules CK-666 and CK- ...... ivating conformational change.
@en
prefLabel
Small molecules CK-666 and CK- ...... ivating conformational change.
@en
P2093
P2860
P1476
Small molecules CK-666 and CK- ...... ivating conformational change.
@en
P2093
Brad J Nolen
Byron Hetrick
Luke A Helgeson
Min Suk Han
P2860
P304
P356
10.1016/J.CHEMBIOL.2013.03.019
P577
2013-04-25T00:00:00Z