Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.
about
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.Making better CRISPR librariesExamination of CRISPR/Cas9 design tools and the effect of target site accessibility on Cas9 activity.Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression.Transcriptional reprogramming in yeast using dCas9 and combinatorial gRNA strategies.The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells.Nucleosomes Selectively Inhibit Cas9 Off-target Activity at a Site Located at the Nucleosome Edge.Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing.Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes.Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting.A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease.Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies.Internal Structure and Preferential Protein Binding of Colloidal Aggregates.Targeted genome editing in Caenorhabditis elegans using CRISPR/Cas9.Evaluation and rational design of guide RNAs for efficient CRISPR/Cas9-mediated mutagenesis in Ciona.CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape.CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance.Deep mutational scanning of S. pyogenes Cas9 reveals important functional domains.The Latest Twists in Chromatin Remodeling.Modulating Gene Expression in Epstein-Barr Virus (EBV)-Positive B Cell Lines with CRISPRa and CRISPRi.A Survey of Validation Strategies for CRISPR-Cas9 Editing.Multiplexed Transcriptional Activation or Repression in Plants Using CRISPR-dCas9-Based Systems.OCT4/POU5F1 is required for NANOG expression in bovine blastocysts.Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio).Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells.Design principles for nuclease-deficient CRISPR-based transcriptional regulators.The Current State and Future of CRISPR-Cas9 gRNA Design ToolsLive-Cell Imaging of Chromatin Condensation Dynamics by CRISPRMultiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and DegenerationNucleosomes inhibit target cleavage by CRISPR-Cas9 in vivoThe interaction landscape between transcription factors and the nucleosome
P2860
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P2860
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.
@en
type
label
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.
@en
prefLabel
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.
@en
P2093
P2860
P356
P1433
P1476
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.
@en
P2093
Fuguo Jiang
Geeta J Narlikar
R Stefan Isaac
Ricardo Almeida
Wendell A Lim
P2860
P356
10.7554/ELIFE.13450
P407
P577
2016-04-28T00:00:00Z