Stabilization of the 53,000-dalton nonviral tumor antigen is not required for transformation by simian virus 40.
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Stable T-p53 complexes are not required for replication of simian virus 40 in culture or for enhanced phosphorylation of T antigen and p53.Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation.The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.The simian virus 40 sequences between 0.169 and 0.423 map units are not essential to immortalize early-passage rat embryo cells.Two classes of transformation-deficient, immortalization-positive simian virus 40 mutants constructed by making three-base insertions in the T antigen gene.Overproduction of protein p53 contributes to simian virus 40-mediated transformation.A fragment of the simian virus 40 early genome can induce tumors in nude mice.Simian virus 40 sequences between 0.168 and 0.424 map units are not required for abortive transformationImmortalization of human fibroblasts transformed by origin-defective simian virus 40Simian virus 40 deletion mutants that transform with reduced efficiency.Energy requirement for degradation of tumor-associated protein p53Less than 40% of the simian virus 40 large T-antigen-coding sequence is required for transformationProperties of a simian virus 40 mutant T antigen substituted in the hydrophobic region: defective ATPase and oligomerization activities and altered phosphorylation accompany an inability to complex with cellular p53.Large-T-antigen-p53 complex formation is not cold sensitive in a cold-sensitive transformant induced by simian virus 40 mutant tsA1499.Evidence for free and metabolically stable p53 protein in nuclear subfractions of simian virus 40-transformed cells.
P2860
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P2860
Stabilization of the 53,000-dalton nonviral tumor antigen is not required for transformation by simian virus 40.
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年論文
@yue
1983年論文
@zh-hant
1983年論文
@zh-hk
1983年論文
@zh-mo
1983年論文
@zh-tw
1983年论文
@wuu
1983年论文
@zh
1983年论文
@zh-cn
name
Stabilization of the 53,000-da ...... sformation by simian virus 40.
@en
type
label
Stabilization of the 53,000-da ...... sformation by simian virus 40.
@en
prefLabel
Stabilization of the 53,000-da ...... sformation by simian virus 40.
@en
P2093
P2860
P356
P1476
Stabilization of the 53,000-da ...... sformation by simian virus 40.
@en
P2093
E G Gurney
L M Sompayrac
P2860
P304
P356
10.1128/MCB.3.2.290
P407
P577
1983-02-01T00:00:00Z