Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release.
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ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapsesDistinct initial SNARE configurations underlying the diversity of exocytosisStructural and functional analysis of tomosyn identifies domains important in exocytotic regulationGene-class analysis of expression patterns induced by psychoactive pharmaceutical exposure in fathead minnow (Pimephales promelas) indicates induction of neuronal systems.Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats.Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.Tomosyn interacts with the SUMO E3 ligase PIASγ.Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4Differential interaction of tomosyn with syntaxin and SNAP25 depends on domains in the WD40 β-propeller core and determines its inhibitory activity.In vivo analysis of conserved C. elegans tomosyn domains.Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulationPlatelet secretion and hemostasis require syntaxin-binding protein STXBP5.Tomosyn expression pattern in the mouse hippocampus suggests both presynaptic and postsynaptic functions.Differential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1.Tomosyn-dependent regulation of synaptic transmission is required for a late phase of associative odor memoryPresynaptic LTP and LTD of excitatory and inhibitory synapsesA Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.Molecular underpinnings of synaptic vesicle pool heterogeneity.Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons.Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory.Reciprocal intramolecular interactions of tomosyn control its inhibitory activity on SNARE complex formation.Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse modelsFriends and foes in synaptic transmission: the role of tomosyn in vesicle priming.Asian Citrus Psyllid RNAi Pathway - RNAi evidence.Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice.Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.Platelet secretory behaviour: as diverse as the granules … or not?The Sec1/Munc18 Protein Groove Plays a Conserved Role in Interaction with Sec9p/SNAP-25.Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy.Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.Dopamine Release Suppression Dependent on an Increase of Intracellular Ca(2+) Contributed to Rotenone-induced Neurotoxicity in PC12 Cells.Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn-1 gene.Effects of thyroxin and donepezil on hippocampal acetylcholine content and syntaxin-1 and munc-18 expression in adult rats with hypothyroidism.Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a.The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.Inhibitory neuron-specific Cre-dependent red fluorescent labeling using VGAT BAC-based transgenic mouse lines with identified transgene integration sites.Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.SNARE protein expression in synaptic terminals and astrocytes in the adult hippocampus: a comparative analysis.
P2860
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P2860
Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Dual inhibition of SNARE compl ...... lled neurotransmitter release.
@en
type
label
Dual inhibition of SNARE compl ...... lled neurotransmitter release.
@en
prefLabel
Dual inhibition of SNARE compl ...... lled neurotransmitter release.
@en
P2093
P2860
P356
P1476
Dual inhibition of SNARE compl ...... lled neurotransmitter release.
@en
P2093
Hiroyoshi Ishizaki
Jun Miyoshi
Kouki Nishikawa
Michiko Nakamura
Miki Okamoto-Tanaka
Sumiko Mochida
Toshiaki Sakisaka
Toshiya Manabe
Yasunori Yamamoto
Yoshimi Takai
P2860
P304
P356
10.1083/JCB.200805150
P407
P577
2008-10-01T00:00:00Z