ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation - Wikidata - awgldk - TriplyDB

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

http://www.wikidata.org/entity/Q36941509

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Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy Radioresistance of Brain Tumors DNA repair targeted therapy: The past or future of cancer treatment?Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Targeting the Checkpoint to Kill Cancer Cells Autophagy and radiosensitization in cancer Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells Radiation and ATM inhibition: the heart of the matter A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme.Tug of war between survival and death: exploring ATM function in cancer.Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma.Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug.ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation.Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin.Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma.New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity.Genomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM.Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer.Revisiting p53 for cancer-specific chemo- and radiotherapy: ten years after.Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways.Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1α through reducing endogenous GSH and inhibiting HIF-1α.Transglutaminase 2 Inhibitor KCC009 Induces p53-Independent Radiosensitization in Lung Adenocarcinoma Cells.Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.High resistance to X-rays and therapeutic carbon ions in glioblastoma cells bearing dysfunctional ATM associates with intrinsic chromosomal instability.Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019.Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation.Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase.Radiosensitization of cancer stem cells in glioblastoma by the simultaneous inhibition of parallel DNA damage response pathways.DNA Damage Response in Human Stem Cells and Neural Descendants.The Future of Radiobiology.Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer.A molecular view of the radioresistance of gliomas.Directing the use of DDR kinase inhibitors in cancer treatment.

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P2860

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

http://www.wikidata.org/entity/Q36941509

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

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ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

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prefLabel

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

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1078-0432.CCR-12-3408

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Clinical Cancer Research

P1476

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

@en

P2093

Alan Lau

http://www.w3.org/2001/XMLSchema#string

Alison F Wagner

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Ashraf Khalil

http://www.w3.org/2001/XMLSchema#string

Bret R Adams

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David G Temesi

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Donna Gilfor

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Elizabeth Rosenberg

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Jason M Beckta

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Kevin S Choe

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Kristoffer Valerie

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P2860

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions

The DNA-damage response in human biology and disease

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

The combined status of ATM and p53 link tumor development with therapeutic response

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Identification of human brain tumour initiating cells

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3189-3200

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10.1158/1078-0432.CCR-12-3408

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12

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2013-04-25T00:00:00Z

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23620409

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3687028

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