Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. - Wikidata - awgldk - TriplyDB

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

http://www.wikidata.org/entity/Q36943690

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Mitochondria in the diabetic heart New Molecular Insights of Insulin in Diabetic Cardiomyopathy Mitochondrial Mechanisms in Septic Cardiomyopathy Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?Mitochondrial stress and the pathogenesis of diabetic neuropathy Mitochondrial morphology in metabolic diseases Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction Mitochondrial hormesis and diabetic complications Mitochondria in the pathogenesis of diabetes: a proteomic view Protective mechanisms of mitochondria and heart function in diabetes Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic Heart Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy Insulin Signaling and Heart Failure.Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study.Insulin signaling regulates mitochondrial function in pancreatic beta-cells Superoxide production by mitochondria of insulin-sensitive tissues: mechanistic differences and effect of early diabetes.Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Decreased long-chain fatty acid oxidation impairs postischemic recovery of the insulin-resistant rat heart.Effects of 1,25-dihydroxyvitamin D3 on pathological changes in rats with diabetic cardiomyopathy.Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction The regulation and turnover of mitochondrial uncoupling proteins.Diabetic cardiomyopathy, causes and effects.Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.Cardiac contractile function and mitochondrial respiration in diabetes-related mouse models.Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease.Myocardial mitochondrial and contractile function are preserved in mice lacking adiponectin.Updating experimental models of diabetic cardiomyopathy Mitochondrial superoxide and coenzyme Q in insulin-deficient rats: increased electron leak Metabolic alterations induce oxidative stress in diabetic and failing hearts: different pathways, same outcome.Mitochondrial redox studies of oxidative stress in kidneys from diabetic mice.Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity C-Peptide reduces mitochondrial superoxide generation by restoring complex I activity in high glucose-exposed renal microvascular endothelial cells.Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway.

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P2860

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

http://www.wikidata.org/entity/Q36943690

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Type 1 diabetic akita mouse he ...... ncreased uncoupling protein 3.

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Type 1 diabetic akita mouse he ...... ncreased uncoupling protein 3.

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Alfred P McQueen

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Benjamin Wayment

http://www.w3.org/2001/XMLSchema#string

Heather A Theobald

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Heiko Bugger

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Joseph Tuinei

http://www.w3.org/2001/XMLSchema#string

Sheldon E Litwin

http://www.w3.org/2001/XMLSchema#string

Sihem Boudina

http://www.w3.org/2001/XMLSchema#string

Ui Jeong Yun

http://www.w3.org/2001/XMLSchema#string

Vlad G Zaha

http://www.w3.org/2001/XMLSchema#string

Xiao Xuan Hu

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P2860

Superoxide activates mitochondrial uncoupling proteins

Genotoxicity of streptozotocin

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

Protein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes.

Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis.

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts.

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2924-2932

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10.2337/DB08-0079

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11

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57

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18678617

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2570388

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