Targeting CD22 reprograms B-cells and reverses autoimmune diabetes. - Wikidata - awgldk - TriplyDB

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

http://www.wikidata.org/entity/Q36943737

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B cells with regulatory properties in transplantation tolerance Type 1 diabetes: translating mechanistic observations into effective clinical outcomes B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis Administration of anti-CD20 mAb is highly effective in preventing but ineffective in treating chronic graft-versus-host disease while preserving strong graft-versus-leukemia effects B cells and type 1 diabetes ...in mice and men.Efforts to prevent and halt autoimmune beta cell destruction.Alpha4beta7 integrin/MAdCAM-1 adhesion pathway is crucial for B cell migration into pancreatic lymph nodes in nonobese diabetic mice A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice.Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes.Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene Therapeutic targeting of Syk in autoimmune diabetes The gut microbiota modulates glycaemic control and serum metabolite profiles in non-obese diabetic mice An update on the use of NOD mice to study autoimmune (Type 1) diabetes.Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens TIM4 Regulates the Anti-Islet Th2 Alloimmune Response Testing agents for prevention or reversal of type 1 diabetes in rodents.Protective effects of combined intervention with adenovirus vector mediated IL-10 and IGF-1 genes on endogenous islet β cells in nonobese diabetes mice with onset of type 1 diabetes mellitus.The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice.Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses.Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes.Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes B-cell cross-presentation of autologous antigen precipitates diabetes.Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice.Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions.Innate pro-B-cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cells B Cell in Autoimmune Diseases.B-lymphocytes expressing an immunoglobulin specificity recognizing the pancreatic ß-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice.Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes.Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts.Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site.CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells.Targeting B-cells mitigates autoimmune diabetes in NOD mice: what is plan B?Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.Translational Mini-Review Series on B Cell-Directed Therapies: B cell-directed therapy for autoimmune diseases.Effector and regulatory B cells: modulators of CD4+ T cell immunity.B cell depletion in autoimmune diabetes: insights from murine models.Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes

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Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

http://www.wikidata.org/entity/Q36943737

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

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type

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Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

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prefLabel

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

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Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.

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Andrea Vergani

http://www.w3.org/2001/XMLSchema#string

Erxi Wu

http://www.w3.org/2001/XMLSchema#string

Indira Guleria

http://www.w3.org/2001/XMLSchema#string

Jeffrey Bluestone

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Kenneth Law

http://www.w3.org/2001/XMLSchema#string

Kyri Dunussi-Joannopoulos

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Masie Wong

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Mohamed H Sayegh

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Reza Abdi

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Scott Rodig

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P2860

Molecular interactions regulate BCR signal inhibition by CD22 and CD72

Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.

Monoclonal antibodies in the treatment of autoimmune cytopenias.

The NOD mouse model of type 1 diabetes: as good as it gets?

Islet regeneration during the reversal of autoimmune diabetes in NOD mice.

Type 1 diabetes: new perspectives on disease pathogenesis and treatment.

Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models.

Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.

B-cell targeting in rheumatoid arthritis and other autoimmune diseases.

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3013-3024

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10.2337/DB08-0420

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11

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57

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Mollie Jurewicz

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2008-08-08T00:00:00Z

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23158451

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18689692

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2570398

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