Long-range cooperative interactions modulate dimerization in SARS 3CLpro.
about
Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulationsMechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like ProteaseDevelopment of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLproMutation of Asn28 Disrupts the Dimerization and Enzymatic Activity of SARS 3CL proDynamically-driven inactivation of the catalytic machinery of the SARS 3C-like protease by the N214A mutation on the extra domainMutation of Glu-166 blocks the substrate-induced dimerization of SARS coronavirus main protease.Dynamically-driven enhancement of the catalytic machinery of the SARS 3C-like protease by the S284-T285-I286/A mutations on the extra domain.Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activityPotential Broad Spectrum Inhibitors of the Coronavirus 3CLpro: A Virtual Screening and Structure-Based Drug Design Study.X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus.Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activityTherapies for coronaviruses. Part 2: Inhibitors of intracellular life cycle.Activation and maturation of SARS-CoV main protease.Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode.E93R substitution of Escherichia coli FtsZ induces bundling of protofilaments, reduces GTPase activity, and impairs bacterial cytokinesis.
P2860
Q27648944-B7E96615-77F4-4977-9DC6-60E8BE02C6FCQ27649949-DEAB7F90-BB8B-4712-8BA3-3AEE8A0C23C3Q27651072-724FDD55-5ABD-44C3-ADE1-984E48C4EC32Q27660870-A5ED2DA3-9639-4917-871D-567888285272Q28477275-07997449-8516-43DC-A16D-E652B7663A47Q33767743-AA928DCD-789D-41B3-8147-805156AC34ACQ33921124-4110B554-D33B-4CD5-AFEE-18B2A57EDC2AQ35925764-AF5CFFBD-F322-4806-AAC6-F94A39407F47Q35943856-5C2E2EA2-D2D3-4D16-B12B-196E0249885CQ36403490-39EEE5C9-11B7-401E-9BE2-36C5302DB5D9Q36897887-FFAB2688-0914-417A-9D93-7F9313C76F90Q37336376-1C4C3DEB-28AA-4E6E-856E-3D802DBD5446Q37481314-C03561B6-2F48-448C-B480-5797E526E742Q37870810-8710A83B-FF59-4D04-B775-E884AC5663FBQ41884048-0E1C583F-5009-4552-BA22-55BDEBDE9A39Q41967455-056D2506-7663-42D9-8AE9-9AF4113133C5
P2860
Long-range cooperative interactions modulate dimerization in SARS 3CLpro.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Long-range cooperative interactions modulate dimerization in SARS 3CLpro.
@en
type
label
Long-range cooperative interactions modulate dimerization in SARS 3CLpro.
@en
prefLabel
Long-range cooperative interactions modulate dimerization in SARS 3CLpro.
@en
P2860
P356
P1433
P1476
Long-range cooperative interactions modulate dimerization in SARS 3CLpro
@en
P2093
Ernesto Freire
Usman Bacha
P2860
P304
14908-14916
P356
10.1021/BI0616302
P407
P577
2006-12-01T00:00:00Z