The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. - Wikidata - awgldk - TriplyDB

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

http://www.wikidata.org/entity/Q36945956

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Cancer as a Proinflammatory Environment: Metastasis and Cachexia Immune cell interplay in colorectal cancer prognosis Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context.A novel role for ezrin in breast cancer angio/lymphangiogenesis.The impact of human adipose tissue-derived stem cells on breast cancer cells: implications for cell-assisted lipotransfers in breast reconstruction.Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment.Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells.The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1.CCR7 regulates cell migration and invasion through JAK2/STAT3 in metastatic squamous cell carcinoma of the head and neck.WP1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting STAT3/miR-21 axis Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis Hedyotis diffusa Willd. extract suppresses proliferation and induces apoptosis via IL-6-inducible STAT3 pathway inactivation in human colorectal cancer cells.Effect of vascular formed endothelial cell network on the invasive capacity of melanoma using the in vitro 3D co-culture patterning model.Differential roles of STAT3 in the initiation and growth of lung cancer Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth.Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer.Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.The Mycoplasma hyorhinis p37 Protein Rapidly Induces Genes in Fibroblasts Associated with Inflammation and Cancer.Interleukin-6 Stimulates Defective Angiogenesis.Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers.Characterization and Clinical Implication of Th1/Th2/Th17 Cytokines Produced from Three-Dimensionally Cultured Tumor Tissues Resected from Breast Cancer Patients.Modeling selective elimination of quiescent cancer cells from bone marrow.IL-6/STAT3 signaling pathway is activated in plasma cell mastitis.Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells.Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.Tumour exosome integrins determine organotropic metastasis.Constitutive activation of STAT3 in breast cancer cells: A review.Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-κB, P38 MAPK and STAT3 pathways.Cancer prevention and therapy through the modulation of the tumor microenvironment.A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed.Cancer subclonal genetic architecture as a key to personalized medicine.Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment.

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The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

http://www.wikidata.org/entity/Q36945956

description

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

@en

type

label

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

@en

prefLabel

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

@en

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P1476

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

@en

P2093

David Lyden

http://www.w3.org/2001/XMLSchema#string

Dennis Huszar

http://www.w3.org/2001/XMLSchema#string

Donatella Santini

http://www.w3.org/2001/XMLSchema#string

Eirini Bournazou

http://www.w3.org/2001/XMLSchema#string

Gregoire Altan-Bonnet

http://www.w3.org/2001/XMLSchema#string

Jacqueline Bromberg

http://www.w3.org/2001/XMLSchema#string

Jared Wels

http://www.w3.org/2001/XMLSchema#string

Jesse Cotari

http://www.w3.org/2001/XMLSchema#string

Katia Manova

http://www.w3.org/2001/XMLSchema#string

Laura Daly

http://www.w3.org/2001/XMLSchema#string

P2860

HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis

GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

Mammary epithelial cell transformation: insights from cell culture and mouse models.

Myeloid-derived suppressor cells as regulators of the immune system

Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis

Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice

Coordinated regulation of myeloid cells by tumours

STATs in cancer inflammation and immunity: a leading role for STAT3

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848-862

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scholarly article

P356

10.1593/NEO.13706

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7

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P478

15

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Claudio Ceccarelli

Elisa de Stanchina

P577

2013-07-01T00:00:00Z

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243970557

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23814496

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3689247

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