Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. - Wikidata - awgldk - TriplyDB

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

http://www.wikidata.org/entity/Q36946535

about

MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development Transcription factor RORα is critical for nuocyte development FOXN1 in thymus organogenesis and development Control of the thymic medulla and its influence on αβT-cell development Notch signaling: its roles and therapeutic potential in hematological malignancies In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity Regulatory gene network circuits underlying T cell development from multipotent progenitors Thymic epithelial cell development and differentiation: cellular and molecular regulation Close link between development and function of gamma-delta T cells DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis Pharmacological inhibition of glycogen synthase kinase 3 regulates T cell development in vitro Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence Sox17 is indispensable for acquisition and maintenance of arterial identity Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation.Evolution of adaptive immune recognition in jawless vertebrates.Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1 ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression Thymic homing of activated CD4+ T cells induces degeneration of the thymic epithelium through excessive RANK signaling.Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.Engineering the human thymic microenvironment to support thymopoiesis in vivo.Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis Notch dimerization is required for leukemogenesis and T-cell development.From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Molecular and cellular basis of T cell lineage commitment.E proteins and the regulation of early lymphocyte development Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses.Regeneration of the aged thymus by a single transcription factor.The role of dendritic cells in tissue-specific autoimmunity.Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.Context- and cell-dependent effects of Delta-like 4 targeting in the bone marrow microenvironment.Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development.T-cell differentiation of multipotent hematopoietic cell line EML in the OP9-DL1 coculture system.A simple model system enabling human CD34(+) cells to undertake differentiation towards T cells Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis.

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P2860

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

http://www.wikidata.org/entity/Q36946535

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Delta-like 4 is the essential, ...... mic T cell lineage commitment.

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type

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Delta-like 4 is the essential, ...... mic T cell lineage commitment.

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Delta-like 4 is the essential, ...... mic T cell lineage commitment.

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P1433

Journal of Experimental Medicine

P1476

Delta-like 4 is the essential, ...... ymic T cell lineage commitment

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P2093

Emma Fiorini

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H Robson Macdonald

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Karin Schuster-Gossler

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Michel Pierres

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Nancy R Manley

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Ute Koch

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Valerie Besseyrias

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P2860

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development

Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

Expression of the mouse Delta1 gene during organogenesis and fetal development

Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

Dosage-sensitive requirement for mouse Dll4 in artery development

Inducible gene targeting in mice

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus.

Stepwise specification of lymphocyte developmental lineages.

P304

2515-2523

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scholarly article

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10.1084/JEM.20080829

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P433

11

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P478

205

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António Duarte

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2008-09-29T00:00:00Z

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23287303

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18824585

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2571927

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