MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells - Wikidata - awgldk - TriplyDB

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

http://www.wikidata.org/entity/Q36950291

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Strategically targeting MYC in cancer Energy metabolism in neuroblastoma and Wilms tumor Cell Proliferation in Neuroblastoma Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate MYC, Metabolism, and Cancer MYC and metabolism on the path to cancer Mitochondrial targets for pharmacological intervention in human disease Recent advances in live cell imaging of hepatoma cells Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma Small-molecule inhibitors of the Myc oncoprotein Inhibitor of MYC identified in a Kröhnke pyridine library Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.Turning publicly available gene expression data into discoveries using gene set context analysis.Targeting MYC Dependence by Metabolic Inhibitors in Cancer Vitamin D, intermediary metabolism and prostate cancer tumor progression.The REST gene signature predicts drug sensitivity in neuroblastoma cell lines and is significantly associated with neuroblastoma tumor stage.c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells.Targeting of the MYCN protein with small molecule c-MYC inhibitors Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.Binding cavities and druggability of intrinsically disordered proteins.BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle.Small Molecule MYC Inhibitor Conjugated to Integrin-Targeted Nanoparticles Extends Survival in a Mouse Model of Disseminated Multiple Myeloma.Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.Arsenic trioxide sensitizes glioblastoma to a myc inhibitor.Epigenetic changes in cancer by Raman imaging, fluorescence imaging, AFM and scanning near-field optical microscopy (SNOM). Acetylation in normal and human cancer breast cells MCF10A, MCF7 and MDA-MB-231.Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion.Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513.Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.Molecular profiling of childhood cancer: Biomarkers and novel therapies Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause Diagnostic FDG and FDOPA positron emission tomography scans distinguish the genomic type and treatment outcome of neuroblastoma.Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes.Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation.Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer.The myc 3' wnt-responsive element suppresses colonic tumorigenesis.In vivo Reprogramming of Cancer Metabolism by MYC.New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.

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P2860

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

http://www.wikidata.org/entity/Q36950291

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2013 nî lūn-bûn

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MYC inhibition induces metabol ...... lipid droplets in tumor cells

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MYC inhibition induces metabol ...... lipid droplets in tumor cells

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Anna Frenzel

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Christer Einvik

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Hanna Zirath

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Lova Segerström

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Marie Arsenian Henriksson

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Matilda Munksgaard Persson

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Per-Johan Jakobsson

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Sven Påhlman

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Ulrica K Westermark

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P2860

Links between metabolism and cancer

Molecular pathways: tumor cells Co-opt the brain-specific metabolism gene CPT1C to promote survival

Mitochondrial structure, function and dynamics are temporally controlled by c-Myc

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Regulation of cancer cell metabolism

Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death

The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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3690852

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