Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy. - Wikidata - awgldk - TriplyDB

Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.

Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.

http://www.wikidata.org/entity/Q36951623

about

Drug discovery in ophthalmology: past success, present challenges, and future opportunities Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves' ophthalmopathy: a review Graves' ophthalmopathy Increased generation of fibrocytes in thyroid-associated ophthalmopathy.Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-associated ophthalmopathy Phenothiourea sensitizes zebrafish cranial neural crest and extraocular muscle development to changes in retinoic acid and IGF signaling Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes.Disturbances of modulating molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA expressions in the orbital tissue from patients with severe graves' ophthalmopathy Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves' disease immunoglobins Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNA Increased response to oxidative stress challenge in Graves' ophthalmopathy orbital fibroblasts.TSH-Mediated TNFα Production in Human Fibrocytes Is Inhibited by Teprotumumab, an IGF-1R Antagonist.Graves' ophthalmopathy: a review of immunogenetics.Increased expression of TSH receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production.Effects of sequential injections of hepatocyte growth factor and insulin-like growth factor-I on adult rabbit extraocular muscle.TSH-receptor-expressing fibrocytes and thyroid-associated ophthalmopathy.Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-κB.The protective effect of antioxidants on orbital fibroblasts from patients with Graves' ophthalmopathy in response to oxidative stress.Advances in the management of thyroid eye disease Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves' orbitopathy.Inhibiting thyrotropin/insulin-like growth factor 1 receptor crosstalk to treat Graves' ophthalmopathy: studies in orbital fibroblasts in vitro.The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid optic neuropathy.Increased oxidative DNA damage, lipid peroxidation, and reactive oxygen species in cultured orbital fibroblasts from patients with Graves' ophthalmopathy: evidence that oxidative stress has a role in this disorder.TSH/IGF-1 Receptor Cross-Talk Rapidly Activates Extracellular Signal-Regulated Kinases in Multiple Cell Types.Does rituximab improve clinical outcomes of patients with thyroid-associated ophthalmopathy? A systematic review and meta-analysis.Efficacy and safety of mycophenolate mofetil in patients with active moderate-to-severe Graves' orbitopathy.Sinonasal abnormalities in patients with Graves' orbitopathy.

P2860

Q26771638-D34A0724-2A74-4674-BED8-18E0BEFC3E4F Q26776335-6FED525A-92E3-4755-A0E6-4B70C05F7775 Q28274196-AADCC33A-8724-420E-8B61-36B06C4BCB14 Q33586738-9E1EA991-8D13-4601-AF00-A9317D1F707B Q33624477-BBC07C54-B8A4-452D-81CC-4ABB3394B45C Q34008775-E1331BC0-3A8D-4033-AB39-BACC024159F5 Q34130987-29DED5EB-AB1D-436C-881E-6B207D8FB220 Q35012933-476320B8-E921-4DFC-8E24-044250D23985 Q35096870-9CDB31F4-C464-4874-AEC2-729C3FE1C717 Q35153361-032263B5-EEB7-441C-8864-AAF3EFA42539 Q35531750-CEF32638-CBE7-4FB2-A671-F97AF911F77D Q35667567-ECCD5F89-4CDA-46A1-9C13-7F20614B2DC0 Q35731002-CEE96953-6087-47E6-9E91-CD3AC89E82FE Q35921354-85C4D97B-76A7-4952-BF2F-21C06160A62F Q36201302-940CB341-DFA7-4A32-9965-8DCC7796C02B Q36393011-E35B758F-7BC0-408C-8C47-824BBA86D503 Q36422528-EB3DA82F-BA1A-456C-9227-631F7C41F85E Q36846603-AF2F2EF5-6D86-4962-A133-172E1B103A6B Q37012076-C4AD04B7-7BE7-4602-9380-353F1F1606BA Q37017174-A0C1D956-A728-420E-A4E5-358BAD4A5282 Q39093117-C8A715CB-7E43-4991-A5C1-1D197FFF6D19 Q39303459-2311FA46-B6D3-4495-94FB-54D4C1F2AD64 Q43124440-960450A0-F0C0-4F7F-A71F-D7AB0DA1D4E5 Q47761035-34286291-B0B3-48E4-BC2D-2938D74236F5 Q49920960-EC6ADE08-4D32-4BA0-94F0-C46286099DCB Q53057871-7472BFA1-AF31-40D2-8435-52FEE0C9FCED Q53242653-F44AB83C-EDCC-4BFC-849E-26236E7C158C

P2860

Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.

http://www.wikidata.org/entity/Q36951623

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Unique attributes of orbital f ...... oid-associated ophthalmopathy.

@en

type

label

Unique attributes of orbital f ...... oid-associated ophthalmopathy.

@en

prefLabel

Unique attributes of orbital f ...... oid-associated ophthalmopathy.

@en

P1433

Q36951623-383B6931-508E-42EC-ABC9-A9FFB73C238D

P1476

Q36951623-F53896C6-742A-4992-9204-8A7A136E2D70

P2093

Q36951623-1C88F2B2-8946-4C26-B516-C1D79AB5985C

Q36951623-23F154F0-9F10-4BF5-A1FB-6B2146815864

Q36951623-2C572BCD-134A-45AD-A182-D7BEAB3AA549

Q36951623-300F8940-CECD-41EA-B137-7306BBDAB19B

Q36951623-3250F821-7830-4C0D-8543-90A0A3B7283C

Q36951623-4C0189E7-F34C-4DEA-AD12-6F29B689F714

Q36951623-5B08CF6D-7CD8-42A7-827D-F2E9C53CF534

Q36951623-7BCA6971-3392-4626-831E-F7FA85670A5E

Q36951623-8A78202B-163C-4FA0-BB15-94C9D7669044

Q36951623-9100D1F6-100A-49AE-86F0-4B81C602C03F

P2860

Q36951623-092DE8E5-DC1A-4D35-BC5A-8E9AE099E868

Q36951623-109C334A-E2C6-4CAF-AC77-E9EFF7D47CB2

Q36951623-16475A59-27CD-403D-8CB7-E7A281CC2CC0

Q36951623-16D1229D-46B1-4779-BB91-15B910C02128

Q36951623-1977653C-F597-4FDE-B21C-234F5D5A2EB7

Q36951623-2BEA6341-8EE9-48A4-8DB5-D67D98E55EFF

Q36951623-2E160D22-1675-4666-A652-807EB71A346A

Q36951623-338F3677-3638-4C75-BDA5-EA72BEB018B3

Q36951623-348380EE-BA59-4364-9376-21CF5CAB21C5

Q36951623-3BBBCE92-C1B3-4D01-BC43-A1DF0FB3389D

P304

Q36951623-D09FF19C-26F5-4DB4-BEE6-65AC069E58D3

P31

Q36951623-0dc85a21-f683-4cf6-8de8-59bb83ebf69a

Q36951623-A8D5F21F-99B5-4401-8CFE-8C950930A1E4

P356

Q36951623-512C6E97-E80D-47D8-B541-E2066718862F

P433

Q36951623-36404E8E-7DFE-41EA-80C0-3816C69AF34E

P478

Q36951623-AD1E9226-CD17-46DF-90DB-08A449E42DC2

P50

Q36951623-42858A5C-A546-4BA5-847A-2319E6DE9B76

Q36951623-6181E9A3-3723-4A3E-A14C-E561AF433819

Q36951623-94B1CA5F-18C9-40E2-BFCF-F1EDC7F3675F

P577

Q36951623-57028B8B-3D64-47FC-8AF6-A95A253AE7EC

P5875

Q36951623-520B0937-3A7F-4790-AF58-B9714C96058C

P698

Q36951623-057FFF56-4515-452B-B2AB-2EDDACE89EBD

P932

Q36951623-C391C420-F38D-40BE-8D44-39505CEEEBF2

P356

P1433

P1476

Unique attributes of orbital f ...... roid-associated ophthalmopathy

@en

P2093

Andrew G Gianoukakis

http://www.w3.org/2001/XMLSchema#string

Beiling Chen

http://www.w3.org/2001/XMLSchema#string

Chieh Chih Tsai

http://www.w3.org/2001/XMLSchema#string

Chris Press

http://www.w3.org/2001/XMLSchema#string

Chris S King

http://www.w3.org/2001/XMLSchema#string

Mei-Ju Shih

http://www.w3.org/2001/XMLSchema#string

Richard P Phipps

http://www.w3.org/2001/XMLSchema#string

Robert A Goldberg

http://www.w3.org/2001/XMLSchema#string

Rui Han

http://www.w3.org/2001/XMLSchema#string

Shanli Tsui

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes

Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts.

Transforming growth factor-beta, basement membrane, and epithelial-mesenchymal transdifferentiation: implications for fibrosis in kidney disease.

Insights into the pathogenesis of thyroid-associated orbitopathy: evolving rationale for therapy.

Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes.

Current perspective on the pathogenesis of Graves' disease and ophthalmopathy.

The use of TNF-alpha blocking agents in rheumatoid arthritis: an overview.

Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions.

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.

Connective tissue, glycosaminoglycans, and diseases of the thyroid.

P304

983-988

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1089/THY.2007.0404

http://www.w3.org/2001/XMLSchema#string

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

18

http://www.w3.org/2001/XMLSchema#string

P50

Raymond S Douglas

P577

2008-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23254496

http://www.w3.org/2001/XMLSchema#string

P698

18788919

http://www.w3.org/2001/XMLSchema#string

P932

2574420

http://www.w3.org/2001/XMLSchema#string