2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes.
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Metabolism and metabolites of polychlorinated biphenylsChiral polychlorinated biphenyl transport, metabolism, and distribution: a review.PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanismsClearance of polychlorinated biphenyl atropisomers is enantioselective in female C57Bl/6 miceAssessment of the disposition of chiral polychlorinated biphenyls in female mdr 1a/b knockout versus wild-type mice using multivariate analyses.2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomesChiral polychlorinated biphenyls: absorption, metabolism and excretion--a reviewAssigning atropisomer elution orders using atropisomerically enriched polychlorinated biphenyl fractions generated by microsomal metabolism.Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers.Seasonal influences on PCB retention and biotransformation in fishChlordane and heptachlor are metabolized enantioselectively by rat liver microsomesEnantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2Stereoselective formation of mono- and dihydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1.Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent.Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences.Glucocorticoids and phenobarbital induce murine CYP2B genes by independent mechanisms.Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites.Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.Microsomal Metabolism of Prochiral Polychlorinated Biphenyls Results in the Enantioselective Formation of Chiral Metabolites.Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example.Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro.Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice.Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs).
P2860
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P2860
2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
2,2',3,3',6,6'-Hexachlorobiphe ...... somal cytochrome P450 enzymes.
@en
type
label
2,2',3,3',6,6'-Hexachlorobiphe ...... somal cytochrome P450 enzymes.
@en
prefLabel
2,2',3,3',6,6'-Hexachlorobiphe ...... somal cytochrome P450 enzymes.
@en
P2093
P2860
P356
P1476
2,2',3,3',6,6'-Hexachlorobiphe ...... somal cytochrome P450 enzymes.
@en
P2093
Eugene G Hrycay
Hans-Joachim Lehmler
Izabela Kania-Korwel
Stelvio M Bandiera
P2860
P304
P356
10.1021/TX800059J
P577
2008-05-22T00:00:00Z