Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage - Wikidata - awgldk - TriplyDB

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

http://www.wikidata.org/entity/Q36954453

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Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies A review of the association between osteosarcoma metastasis and protein translation Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation Long noncoding RNAs in the progression, metastasis, and prognosis of osteosarcoma Differential impact of tumor suppressor pathways on DNA damage response and therapy-induced transformation in a mouse primary cell model Osteosarcomagenesis: modeling cancer initiation in the mouse.Microarray and ChIP-seq data analysis revealed changes in p53-mediated transcriptional regulation in Nutlin-3-treated U2OS cells Polyoma virus-induced osteosarcomas in inbred strains of mice: host determinants of metastasis.Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas Genetically transforming human osteoblasts to sarcoma: development of an osteosarcoma model.Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms.Osteosarcoma Overview.Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model.The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma Animal models in osteosarcoma.Side population cells isolated from human osteosarcoma are enriched with tumor-initiating cells.Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice Animal models of soft-tissue sarcoma.Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen.Notch activation as a driver of osteogenic sarcoma.Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma.Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease The Role of RUNX2 in Osteosarcoma Oncogenesis.Epigenetic regulation of apoptosis and cell cycle in osteosarcoma CD99 drives terminal differentiation of osteosarcoma cells by acting as a spatial regulator of ERK 1/2.Mesenchymal stem cell transformation and sarcoma genesis.Acute lymphoid leukemia cells with greater stem cell antigen-1 (Ly6a/Sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivo.Conditional inactivation of the CXCR4 receptor in osteoprecursors reduces postnatal bone formation due to impaired osteoblast development.Primary neoplasms of bones in mice: retrospective study and review of literature Transgenic and knockout mice models to reveal the functions of tumor suppressor genes.p53 loss increases the osteogenic differentiation of bone marrow stromal cells mTORC1 maintains the tumorigenicity of SSEA-4(+) high-grade osteosarcoma.The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice.

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P2860

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

http://www.wikidata.org/entity/Q36954453

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2008 nî lūn-bûn

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2008年论文

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2008年论文

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2008年论文

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name

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

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Proceedings of the National Academy of Sciences of the United States of America

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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

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Alicia Caron

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Allison S Landman

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Borel Djouedjong Fonhoue

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Eliezer Calo

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Emily S Miller

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Jacqueline A Lees

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Julie C West

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Paul S Danielian

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Roderick Bronson

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Seth D Berman

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P2860

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

Developmental defects and tumor predisposition in Rb mutant mice.

Mesenchymal stem cell features of Ewing tumors.

Li-Fraumeni syndrome: a p53 family affair.

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling.

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice

Molecular pathogenesis of osteosarcoma.

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Mary L Bouxsein

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23165770

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