An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice
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Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathyMouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac diseaseScaffold Proteins Regulating Extracellular Regulated Kinase Function in Cardiac Hypertrophy and DiseaseEpigenetic regulation by histone demethylases in hypoxiaTitin-based tension in the cardiac sarcomere: molecular origin and physiological adaptationsHistone methylations in heart development, congenital and adult heart diseasesPathophysiological defects and transcriptional profiling in the RBM20-/- rat modelSarcOptiM for ImageJ: high-frequency online sarcomere length computing on stimulated cardiomyocytesThe histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in miceAblation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathyGenetic epidemiology of titin-truncating variants in the etiology of dilated cardiomyopathy.Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart.Mechano-signaling in heart failurePressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.Aggresome-Autophagy Involvement in a Sarcopenic Patient with Rigid Spine Syndrome and a p.C150R Mutation in FHL1 GeneGenetics of mechanosensation in the heart.MLP (muscle LIM protein) as a stress sensor in the heart.Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.Probing muscle ankyrin-repeat protein (MARP) structure and functionEpigenetic regulation of cardiac myocyte differentiation.Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy.The giant protein titin: a regulatory node that integrates myocyte signaling pathways.Cardiac titin and heart disease.Muscle giants: molecular scaffolds in sarcomerogenesis.Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice.Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodelingIdentification of an FHL1 protein complex containing gamma-actin and non-muscle myosin IIB by analysis of protein-protein interactions.Identification of New SRF Binding Sites in Genes Modulated by SRF Over-Expression in Mouse HeartsFhl1 W122S causes loss of protein function and late-onset mild myopathy.Emerging importance of oxidative stress in regulating striated muscle elasticity.Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.Mechanotransduction in cardiac hypertrophy and failure.The sarcomeric Z-disc and Z-discopathies.Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies.Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle ForceThe multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.
P2860
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P2860
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
An FHL1-containing complex wit ...... nical stress responses in mice
@en
type
label
An FHL1-containing complex wit ...... nical stress responses in mice
@en
prefLabel
An FHL1-containing complex wit ...... nical stress responses in mice
@en
P2093
P2860
P356
P1476
An FHL1-containing complex wit ...... nical stress responses in mice
@en
P2093
Andrea A Domenighetti
Andrew D McCulloch
Anna Raskin
Farah Sheikh
Gerald W Dorn
Jeffrey H Omens
Joan Heller Brown
Kirk L Peterson
Ming Zheng
P2860
P304
P356
10.1172/JCI34472
P407
P577
2008-11-03T00:00:00Z