Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.
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The basics of epithelial-mesenchymal transition5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesisFibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosisDown-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases.Inflammation and Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fighting Against Multiple OpponentsAbalone visceral extract inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity.PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis.Antitumor activity of total flavonoids from Tetrastigma hemsleyanum Diels et Gilg is associated with the inhibition of regulatory T cells in mice.Mechanisms of the epithelial-mesenchymal transition by TGF-betaPGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer.Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.Role of the prostaglandin E2/E-prostanoid 2 receptor signalling pathway in TGFβ-induced mice mesangial cell damage.Transforming growth factor-β and the hallmarks of cancer.Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantationLysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-β signaling in breast cancer cells.TGF-β Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells.TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-β1.Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis.HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGFβ-signaling in hypoxic microenvironmentThe Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cellsThe potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study.S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer.Anti-tumor enhancement of Fei-Liu-Ping ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse modelPrognostic value of transforming growth factor-beta in patients with colorectal cancer who undergo surgery: a meta-analysisCCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer.Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib.A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy.Role of the Slug Transcription Factor in Chemically-Induced Skin CancerIntegrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma.TGF-β effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway.Biologic determinants of tumor recurrence in stage II colon cancer: validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581.The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells.Noncanonical TGF-β signaling during mammary tumorigenesis.Role of TGF-β and the tumor microenvironment during mammary tumorigenesisDeconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression.The relevance of the TGF-β Paradox to EMT-MET programsThe biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.The TGF-beta paradox in human cancer: an update.
P2860
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P2860
Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cox-2 inactivates Smad signali ...... h a PGE2-dependent mechanisms.
@en
type
label
Cox-2 inactivates Smad signali ...... h a PGE2-dependent mechanisms.
@en
prefLabel
Cox-2 inactivates Smad signali ...... h a PGE2-dependent mechanisms.
@en
P2093
P2860
P356
P1433
P1476
Cox-2 inactivates Smad signali ...... h a PGE2-dependent mechanisms.
@en
P2093
Jason R Neil
Kyle M Johnson
Raphael A Nemenoff
William P Schiemann
P2860
P304
P356
10.1093/CARCIN/BGN202
P407
P577
2008-08-25T00:00:00Z