Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors
about
Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafAThe role of epigenetics in the pathology of diabetic complicationsEpigenetics: a molecular link between environmental factors and type 2 diabetesHistone Acetylation and Its Modifiers in the Pathogenesis of Diabetic NephropathyRecent developments in β-cell differentiation of pluripotent stem cells induced by small and large moleculesNutrition, epigenetics, and metabolic syndromeHuman genetics of diabetic vascular complicationsWhich stem cells to repair the endocrine pancreas?Translational implications of the β-cell epigenome in diabetes mellitusNatural history of β-cell adaptation and failure in type 2 diabetesEpigenetic Regulation of Islet Development and RegenerationHistone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic childrenSmall-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouseChild health, developmental plasticity, and epigenetic programmingEpigenomic plasticity enables human pancreatic α to β cell reprogramming.Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma.Revealing transcription factors during human pancreatic β cell development.OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.Potential of epigenetic therapies in non-cancerous conditions.A small-molecule inducer of PDX1 expression identified by high-throughput screening.A systems view of epigenetic networks regulating pancreas development and β-cell functionSpecific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.Organogenesis and functional genomics of the endocrine pancreasDeconstructing pancreas developmental biology.Chemical methods to induce Beta-cell proliferation.Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cellsActivation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cell differentiation in ratsValproic Acid Increases the Hepatic Differentiation Potential of Salivary Gland CellsValproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation ProgramsDirect differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules.Reprogramming adult human dermal fibroblasts to islet-like cells by epigenetic modification coupled to transcription factor modulation.Targeting histone deacetylases for the treatment of diseaseExpression levels of histone deacetylases determine the cell fate of hematopoietic progenitors.The hexosamine biosynthesis pathway is essential for pancreatic beta cell development.Molecular and cellular regulation of pancreatic acinar cell function.Oxygen: a master regulator of pancreatic development?Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetesHistone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.Epigenetics and diabetes treatment: an unrealized promise?
P2860
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P2860
Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Histone deacetylase inhibitors ...... amplify endocrine progenitors
@en
type
label
Histone deacetylase inhibitors ...... amplify endocrine progenitors
@en
prefLabel
Histone deacetylase inhibitors ...... amplify endocrine progenitors
@en
P2860
P356
P1476
Histone deacetylase inhibitors ...... amplify endocrine progenitors
@en
P2093
Olivia Lenoir
P2860
P304
P356
10.1128/MCB.00413-08
P407
P577
2008-08-18T00:00:00Z