Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8(+) T cells and dendritic cells.
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Cytotoxic granule secretion by lymphocytes and its link to immune homeostasisFailed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosisPathophysiology of Pediatric Multiple Organ Dysfunction Syndrome.An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndromePerforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption.Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling.ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice.Evaluation of macrophage activation syndrome associated with systemic juvenile idiopathic arthritis: single center experience over a one-year period.Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption.Mixed hematopoietic or T-cell chimerism above a minimal threshold restores perforin-dependent immune regulation in perforin-deficient mice.Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and miceEliminating encephalitogenic T cells without undermining protective immunityStaying alive: cell death in antiviral immunity.Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis.Genetic defects in cytolysis in macrophage activation syndrome.Ebola Virus Disease has Features of Hemophagocytic Lymphohistiocytosis Syndrome.High Level of Perforin Expression Is Required for Effective Correction of Hemophagocytic Lymphohistiocytosis.Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: differences and similarities.How to Treat Involvement of the Central Nervous System in Hemophagocytic Lymphohistiocytosis?Finding a Balance between Protection and Pathology: The Dual Role of Perforin in Human Disease.How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis.Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis.The cathelicidin protein CRAMP is a potential atherosclerosis self-antigen in ApoE(-/-) mice.T cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents Haemophagocytic Lymphohistiocytosis manifestations.Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation.Hemophagocytic lymphohistiocytosis: Pathogenesis, diagnosis, and management.Successful Allogeneic Hematopoietic Stem Cell Transplantation in XIAP Deficiency Using Reduced-Intensity Conditioning.Adult-Onset Still's Disease and Macrophage-Activating Syndrome Progressing to Lymphoma: A Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special SurgeryT Cells in Adipose Tissue: Critical Players in Immunometabolism
P2860
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P2860
Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8(+) T cells and dendritic cells.
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
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2013年论文
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2013年论文
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name
Perforin deficiency impairs a ...... ) T cells and dendritic cells.
@en
type
label
Perforin deficiency impairs a ...... ) T cells and dendritic cells.
@en
prefLabel
Perforin deficiency impairs a ...... ) T cells and dendritic cells.
@en
P2860
P1433
P1476
Perforin deficiency impairs a ...... ) T cells and dendritic cells.
@en
P2093
Catherine E Terrell
Michael B Jordan
P2860
P304
P356
10.1182/BLOOD-2013-04-495309
P407
P577
2013-05-09T00:00:00Z