Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains.
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Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channelStructure of the human BK channel Ca2+-activation apparatus at 3.0 A resolutionStructure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channelBK channels: multiple sensors, one activation gateStructural basis for calcium and magnesium regulation of a large conductance calcium-activated potassium channel with β1 subunitsA linkage analysis toolkit for studying allosteric networks in ion channels.Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy.A BK (Slo1) channel journey from molecule to physiology.Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.Cryo-EM structure of the open high-conductance Ca2+-activated K+ channelA comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangementsBK channel activation: structural and functional insightsA charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.Ion sensing in the RCK1 domain of BK channels.Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.Intrinsic disorder in the BK channel and its interactome.Mitochondrial BKCa channelPatch clamp and perfusion techniques for studying ion channels expressed in Xenopus oocytesMg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevatedThe contribution of RCK domains to human BK channel allosteric activationLarge conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing.Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.Interaction between residues in the Mg2+-binding site regulates BK channel activationCryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating.Transduction of voltage and Ca2+ signals by Slo1 BK channels.Molecular mechanisms of BK channel activation.A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ringAllosteric interactions and the modular nature of the voltage- and Ca2+-activated (BK) channel.BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.Targeting BK (big potassium) channels in epilepsy.Mechanism of electromechanical coupling in voltage-gated potassium channels.
P2860
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P2860
Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Activation of Slo1 BK channels ...... ltage sensor and RCK1 domains.
@en
type
label
Activation of Slo1 BK channels ...... ltage sensor and RCK1 domains.
@en
prefLabel
Activation of Slo1 BK channels ...... ltage sensor and RCK1 domains.
@en
P2093
P2860
P356
P1476
Activation of Slo1 BK channels ...... ltage sensor and RCK1 domains.
@en
P2093
Guohui Zhang
Huanghe Yang
Jianmin Cui
Jingyi Shi
Junqiu Yang
Kelli Delaloye
P2860
P2888
P304
P356
10.1038/NSMB.1507
P577
2008-10-19T00:00:00Z