Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. - Wikidata - awgldk - TriplyDB

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.

http://www.wikidata.org/entity/Q36972337

about

Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma Variant base excision repair proteins: contributors to genomic instability Pathways for repairing and tolerating the spectrum of oxidative DNA lesions Base excision repair and cancer A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer Base excision repair Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines.No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.Inhibition of DNA glycosylases via small molecule purine analogs DNA repair and the accumulation of oxidatively damaged DNA are affected by fruit intake in mice Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.Defective repair of oxidative base lesions by the DNA glycosylase Nth1 associates with multiple telomere defects.Interplay between DNA repair and inflammation, and the link to cancer New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice.Base excision repair in physiology and pathology of the central nervous system Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage.Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.Regulation of DNA glycosylases and their role in limiting disease.The role of DNA repair in brain related disease pathology.Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair.Base excision repair in the mammalian brain: implication for age related neurodegeneration Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.Mechanisms of base substitution mutagenesis in cancer genomes.DNA glycosylases search for and remove oxidized DNA bases.Molecular targets of oxidative stress.A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens.Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems.Oxidative DNA damage in disease--insights gained from base excision repair glycosylase-deficient mouse models.Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques.Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability Hypersensitivity of mouse NEIL1-knockdown cells to hydrogen peroxide during S phase.Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure.

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Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.

http://www.wikidata.org/entity/Q36972337

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

Targeted deletion of the genes ...... genic oxidative damage to DNA.

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type

label

Targeted deletion of the genes ...... genic oxidative damage to DNA.

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prefLabel

Targeted deletion of the genes ...... genic oxidative damage to DNA.

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J.DNAREP.2009.03.001

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Targeted deletion of the genes ...... ogenic oxidative damage to DNA

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Güldal Kirkali

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Karen L Koenig

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Maria T Ocampo-Hafalla

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Michael K Chan

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Miral Dizdaroglu

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Pawel Jaruga

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R Stephen Lloyd

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Vladimir Vartanian

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P2860

In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue

Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

Base-excision repair of oxidative DNA damage

Novel substrates of Escherichia coli nth protein and its kinetics for excision of modified bases from DNA damaged by free radicals.

Forensic applications of laser capture microdissection: use in DNA-based parentage testing and platform validation.

Complementary techniques: laser capture microdissection--increasing specificity of gene expression profiling of cancer specimens.

Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites

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786-794

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10.1016/J.DNAREP.2009.03.001

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7

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8

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Stuart M. Brown

George W Teebor

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2009-04-05T00:00:00Z

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19346169

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4894318

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