Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit. - Wikidata - awgldk - TriplyDB

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.

http://www.wikidata.org/entity/Q36972632

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BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry.Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line Amitozyn impairs chromosome segregation and induces apoptosis via mitotic checkpoint activation Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.BubR1 is modified by sumoylation during mitotic progression Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing.Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation Mitotic catenation is monitored and resolved by a PKCε-regulated pathway Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability.Separating the spindle, checkpoint, and timer functions of BubR1 CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1.Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.Selective blockade of cancer cell proliferation and anchorage-independent growth by Plk1 activity-dependent suicidal inhibition of its polo-box domain Use of the protein ontology for multi-faceted analysis of biological processes: a case study of the spindle checkpoint BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes.Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex BUB1 and BUBR1: multifaceted kinases of the cell cycle.Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint Mitosis as an anti-cancer drug target.Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.Playing polo during mitosis: PLK1 takes the lead.Hydrophobic bile acid-induced micronuclei formation, mitotic perturbations, and decreases in spindle checkpoint proteins: relevance to genomic instability in colon carcinogenesis.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Kinase signaling in the spindle checkpoint.Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen Mechanisms of kinetochore-microtubule attachment errors in mammalian oocytes.The GPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER.

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P2860

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.

http://www.wikidata.org/entity/Q36972632

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Phosphorylation sites in BubR1 ...... nt, tension, and mitotic exit.

@en

type

label

Phosphorylation sites in BubR1 ...... nt, tension, and mitotic exit.

@en

prefLabel

Phosphorylation sites in BubR1 ...... nt, tension, and mitotic exit.

@en

P1433

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P1433

Journal of Cell Biology

P1476

Phosphorylation sites in BubR1 ...... nt, tension, and mitotic exit.

@en

P2093

Francesca Zappacosta

http://www.w3.org/2001/XMLSchema#string

Haomin Huang

http://www.w3.org/2001/XMLSchema#string

James Hittle

http://www.w3.org/2001/XMLSchema#string

Roland S Annan

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments

Aurora B regulates MCAK at the mitotic centromere

The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

Mutations of mitotic checkpoint genes in human cancers

P304

667-680

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10.1083/JCB.200805163

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4

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183

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2008-11-01T00:00:00Z

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23479573

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19015317

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P921

phosphorylation

P932

2582891

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