Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
about
Recent advances in understanding leptin signaling and leptin resistanceSOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokinesThe biology and mechanism of action of suppressor of cytokine signaling 3Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet.Hyperleptinemia directly affects testicular maturation at different sexual stages in mice, and suppressor of cytokine signaling 3 is involved in this process.Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity.Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity.Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesityVentromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.A sensitive period for environmental regulation of eating behavior and leptin sensitivityCombined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance.CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin.Wired on sugar: the role of the CNS in the regulation of glucose homeostasis.SF-1 in the ventral medial hypothalamic nucleus: a key regulator of homeostasisGenetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH.Sixteen years and counting: an update on leptin in energy balanceSteroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus.SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.Hypothalamic inflammation: a double-edged sword to nutritional diseases.Inflammatory cause of metabolic syndrome via brain stress and NF-κB.SOCS, Inflammation, and Autoimmunity.BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior.Hypothalamic ventromedial COUP-TFII protects against hypoglycemia-associated autonomic failure.Leptin, diabetes, and the brainRevisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis.Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle.Ventromedial nucleus neurons are less sensitive to leptin excitation in rats bred to develop diet-induced obesityHypothalamic dysfunction of the thrombospondin receptor α2δ-1 underlies the overeating and obesity triggered by brain-derived neurotrophic factor deficiency.Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues.Central insulin and leptin-mediated autonomic control of glucose homeostasis.CNS regulation of glucose homeostasis.Location, location, location: the CNS sites of leptin action dictate its regulation of homeostatic and hedonic pathways.The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis.The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure.Multiple hypothalamic circuits sense and regulate glucose levelsCentral leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain.CNS control of glucose metabolism: response to environmental challenges.Hypothalamic-autonomic control of energy homeostasis.Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions
P2860
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P2860
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Selective inactivation of Socs ...... without affecting body weight
@en
type
label
Selective inactivation of Socs ...... without affecting body weight
@en
prefLabel
Selective inactivation of Socs ...... without affecting body weight
@en
P2093
P2860
P356
P1433
P1476
Selective inactivation of Socs ...... without affecting body weight
@en
P2093
Akihiko Yoshimura
Bradford B Lowell
Harveen Dhillon
Jeffrey S Flier
P2860
P304
P356
10.1210/EN.2008-0805
P407
P577
2008-07-31T00:00:00Z