The replication of beta cells in normal physiology, in disease and for therapy.
about
Pancreatic β Cell Mass DeathMultipotent pancreas progenitors: Inconclusive but pivotal topicType 1 diabetesAdvancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient miceβ-cell dysfunction: Its critical role in prevention and management of type 2 diabetes.mRNA expression analysis of cell cycle genes in islets of pregnant miceRap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferationEfficacy and Safety of Once-Daily Insulin Degludec/Insulin Aspart versus Insulin Glargine (U100) for 52 Weeks in Insulin-Naïve Patients with Type 2 Diabetes: A Randomized Controlled TrialNon-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion.Incomplete Re-Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β-Cell Dedifferentiation.Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP ratThe Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.Reporter islets in the eye reveal the plasticity of the endocrine pancreasA 3D map of the islet routes throughout the healthy human pancreas.RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes.Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice.Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell massSuccessful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1.Augmented reduction of islet β-cell mass in Goto-Kakizaki rats fed high-fat diet and its suppression by pitavastatin treatment.Recurrence of autoimmunity following pancreas transplantation.Development of factors to convert frequency to rate for beta-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistry.Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Modeling nonsteady-state metabolism from arteriovenous data.GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic β-cells from glucolipotoxicityEndothelium-derived Netrin-4 supports pancreatic epithelial cell adhesion and differentiation through integrins α2β1 and α3β1.Regeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy.Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies.Glucose and aging control the quiescence period that follows pancreatic beta cell replicationProinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells.Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetesMicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells.Calcineurin signaling regulates human islet {beta}-cell survival.Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy.Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds.Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.Diet-induced impaired glucose tolerance and gestational diabetes in the dogGSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1)Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets.Guidelines on the use of extracorporeal photopheresisPostnatal β-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1.
P2860
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P2860
The replication of beta cells in normal physiology, in disease and for therapy.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The replication of beta cells in normal physiology, in disease and for therapy.
@en
type
label
The replication of beta cells in normal physiology, in disease and for therapy.
@en
prefLabel
The replication of beta cells in normal physiology, in disease and for therapy.
@en
P2093
P356
P1476
The replication of beta cells in normal physiology, in disease and for therapy.
@en
P2093
Alexandra E Butler
Anil Bhushan
Juris J Meier
Peter C Butler
P304
P356
10.1038/NCPENDMET0647
P577
2007-11-01T00:00:00Z