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Membrane remodeling and mechanics: Experiments and simulations of α-SynucleinSeeking a mechanism for the toxicity of oligomeric α-synucleinATP13A2 and Alpha-synuclein: a Metal Taste in AutophagyLoss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry.Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cellsα-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease.α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP.Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease.DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function.Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species.A mitocentric view of Parkinson's disease.Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology.Multipronged approach to identify and validate a novel upstream regulator of Sncg in mouse retinal ganglion cells.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Protein Partners of α-Synuclein in Health and Disease.α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease.From the baker to the bedside: yeast models of Parkinson's disease.Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy.Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes.Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease.Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.α-Synuclein's Uniquely Long Amphipathic Helix Enhances its Membrane Binding and Remodeling Capacity.α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling.Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.The Close Encounter Between Alpha-Synuclein and Mitochondria.Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
α-Synuclein and mitochondria: partners in crime?
@en
type
label
α-Synuclein and mitochondria: partners in crime?
@en
prefLabel
α-Synuclein and mitochondria: partners in crime?
@en
P2860
P1433
P1476
α-Synuclein and mitochondria: partners in crime?
@en
P2093
Ken Nakamura
P2860
P2888
P304
P356
10.1007/S13311-013-0182-9
P577
2013-07-01T00:00:00Z