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Therapeutic Implications of Targeting AKT Signaling in MelanomaEstradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cellsCellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressorRoles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implicationsMicroRNA, nutrition, and cancer preventionMembrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflectionConditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosisGenetic alterations in quadruple malignancies of a patient with multiple sclerosis: their role in malignancy development and response to therapy.PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in micePhase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia.Signalling mechanisms regulating phenotypic changes in breast cancer cells.Membrane association of the PTEN tumor suppressor: neutron scattering and MD simulations reveal the structure of protein-membrane complexes.Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient miceTreatment with sodium orthovanadate reduces blood-brain barrier disruption via phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphorylation in experimental subarachnoid hemorrhage.Metformin- A Promising Agent for Chemoprevention in BRCA1 Carriers.Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy.The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.Genetic and biochemical alterations in non-small cell lung cancer.Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancerThe impact of PTEN tumor suppressor gene on acquiring resistance to tamoxifen treatment in breast cancer patientsGenetics of melanomaSpatiotemporal analysis of differential Akt regulation in plasma membrane microdomainsPhosphorylation keeps PTEN phosphatase closed for business.Out, in and back again: PtdIns(4,5)P(2) regulates cadherin trafficking in epithelial morphogenesis.The association of PTEN hypermethylation and breast cancer: a meta-analysisInterconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development.No association between phosphatase and tensin homolog genetic polymorphisms and colon cancerThe PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.In human retinoblastoma Y79 cells okadaic acid-parthenolide co-treatment induces synergistic apoptotic effects, with PTEN as a key player.Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells.Targeting the bone marrow in Waldenstrom macroglobulinemia.Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancerResveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways.Splicing of mouse p53 pre-mRNA does not always follow the "first come, first served" principle and may be influenced by cisplatin treatment and serum starvation.Role of microRNA-21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma.A mutant form of PTEN linked to autismUnsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes.The Sir Hans Krebs Lecture. How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden.Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC.Exosomes Transfer Among Different Species Cells and Mediating miRNAs Delivery.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Why is PTEN an important tumor suppressor?
@en
type
label
Why is PTEN an important tumor suppressor?
@en
prefLabel
Why is PTEN an important tumor suppressor?
@en
P356
P1476
Why is PTEN an important tumor suppressor?
@en
P2093
P304
P356
10.1002/JCB.21593
P577
2007-12-01T00:00:00Z