Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.
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Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibitionEAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300DUBs, New Members in the Hypoxia Signaling clUbTo breathe or not to breathe: the haematopoietic stem/progenitor cells dilemmaHIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionHsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxalA functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus.Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression.Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluationTargeted genes and interacting proteins of hypoxia inducible factor-1.Hypoxia-inducible factor α subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent.Insight into hypoxia tolerance in cowpea bruchid: metabolic repression and heat shock protein regulation via hypoxia-inducible factor 1.A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways.Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis.The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop.Hypoxia-inducible factor as an angiogenic master switchFour-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1Interaction with ErbB4 promotes hypoxia-inducible factor-1α signaling.GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1αHIF1α protein stability is increased by acetylation at lysine 709.Regulation of cell proliferation by hypoxia-inducible factorsFetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal ratsNew strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease.Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation.A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in miceThe VHL/HIF axis in clear cell renal carcinoma.Sirtuin-7 inhibits the activity of hypoxia-inducible factors.Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features.The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.HAF : the new player in oxygen-independent HIF-1alpha degradation.Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway.Molecular responses to hypoxia-inducible factor 1α and beyond.Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes.The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma.Passing the baton: the HIF switch.Transcriptional regulation by hypoxia inducible factors.Future perspectives for mTOR inhibitors in renal cell cancer treatment.Role of Intestinal HIF-2α in Health and Disease.
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P2860
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Hypoxia-associated factor, a n ...... xygen-independent degradation.
@en
type
label
Hypoxia-associated factor, a n ...... xygen-independent degradation.
@en
prefLabel
Hypoxia-associated factor, a n ...... xygen-independent degradation.
@en
P2860
P356
P1476
Hypoxia-associated factor, a n ...... xygen-independent degradation.
@en
P2093
Bryant G Darnay
Mei Yee Koh
P2860
P304
P356
10.1128/MCB.00773-08
P407
P50
P577
2008-10-06T00:00:00Z