Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
about
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malariaDiscovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate DehydrogenasePyrimidine Pathway-Dependent and -Independent Functions of the Toxoplasma gondii Mitochondrial Dihydroorotate Dehydrogenase.Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.Humanized mouse models infected with human Plasmodium species for antimalarial drug discovery.Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits.Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a studySelective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived ConditionsIsoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity
P2860
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P2860
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Tetrahydro-2-naphthyl and 2-In ...... elective Antimalarial Activity
@en
type
label
Tetrahydro-2-naphthyl and 2-In ...... elective Antimalarial Activity
@en
prefLabel
Tetrahydro-2-naphthyl and 2-In ...... elective Antimalarial Activity
@en
P2093
P2860
P50
P1476
Tetrahydro-2-naphthyl and 2-In ...... elective Antimalarial Activity
@en
P2093
Dave Matthews
David Waterson
Didier Leroy
Eileen Ryan
Farah El Mazouni
Iñigo Angulo-Barturen
John White
Jose M Coteron
Julia Morizzi
P2860
P304
P356
10.1021/ACS.JMEDCHEM.6B00275
P407
P577
2016-04-29T00:00:00Z