Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport
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The ABCs of Candida albicans Multidrug Transporter Cdr1A mutation in intracellular loop 4 affects the drug-efflux activity of the yeast multidrug resistance ABC transporter Pdr5pThe amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transportFungal PDR transporters: Phylogeny, topology, motifs and function.The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.The Arabidopsis concentration-dependent influx/efflux transporter ABCB4 regulates cellular auxin levels in the root epidermis.Evidence for a molecular diode-based mechanism in a multispecific ATP-binding cassette (ABC) exporter: SER-1368 as a gatekeeping residue in the yeast multidrug transporter Pdr5Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter.Uncoupling substrate transport from ATP hydrolysis in the Escherichia coli maltose transporter.Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: a molecular modeling study.Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p.The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transportersEfflux-mediated antifungal drug resistance.The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycle.Multidrug efflux pumps: substrate selection in ATP-binding cassette multidrug efflux pumps--first come, first served?ABC proteins in yeast and fungal pathogens.Efflux pump proteins in antifungal resistance.Candida Efflux ATPases and Antiporters in Clinical Drug Resistance.Efflux Pump Control Alters Synthetic Gene Circuit Function.A novel inhibitor of the LolCDE ABC transporter essential for lipoprotein trafficking in Gram-negative bacteria.Mutations of charged amino acids at the cytoplasmic end of transmembrane helix 2 affect transport activity of the budding yeast multidrug resistance protein Pdr5p.Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity.Activation of signaling pathways related to cell wall integrity and multidrug resistance by organic solvent in Saccharomyces cerevisiae.
P2860
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P2860
Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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name
Mutations define cross-talk be ...... P hydrolysis to drug transport
@en
Mutations define cross-talk be ...... hydrolysis to drug transport.
@nl
type
label
Mutations define cross-talk be ...... P hydrolysis to drug transport
@en
Mutations define cross-talk be ...... hydrolysis to drug transport.
@nl
prefLabel
Mutations define cross-talk be ...... P hydrolysis to drug transport
@en
Mutations define cross-talk be ...... hydrolysis to drug transport.
@nl
P2093
P2860
P356
P1476
Mutations define cross-talk be ...... P hydrolysis to drug transport
@en
P2093
John Golin
Leopold May
Michael P Dougherty
Robert Rutledge
Sherry Supernavage Bohn
Suresh V Ambudkar
Susan Cronin
Zuben E Sauna
P2860
P304
35010-35022
P356
10.1074/JBC.M806446200
P407
P577
2008-10-08T00:00:00Z