Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1
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The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinomaGraded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiologyRenal cell carcinoma development and miRNAs: a possible link to the EGFR pathway.Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway.The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer.Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells.
P2860
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P2860
Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 January 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Von Hippel-Lindau tumor suppre ...... signaling via Akt-1 and MEK-1
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Von Hippel-Lindau tumor suppre ...... signaling via Akt-1 and MEK-1.
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type
label
Von Hippel-Lindau tumor suppre ...... signaling via Akt-1 and MEK-1
@en
Von Hippel-Lindau tumor suppre ...... signaling via Akt-1 and MEK-1.
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prefLabel
Von Hippel-Lindau tumor suppre ...... signaling via Akt-1 and MEK-1
@en
Von Hippel-Lindau tumor suppre ...... signaling via Akt-1 and MEK-1.
@nl
P2093
P2860
P1433
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Von Hippel-Lindau tumor suppre ...... signaling via Akt-1 and MEK-1
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James R Vasselli
Jean-Baptiste Lattouf
Julie Xanthopoulos
S Justin Lee
W Marston Linehan
P2860
P304
P356
10.1016/J.EURURO.2008.01.010
P407
P577
2008-01-16T00:00:00Z