Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.
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Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutationHsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiaeThe different roles of selective autophagic protein degradation in mammalian cellsRecruitment of the oncoprotein v-ErbA to aggresomes.The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodiesThe ubiquitin-proteasome system in spongiform degenerative disordersIndividual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans.Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport.Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Role of Cigarette Smoke-Induced Aggresome Formation in Chronic Obstructive Pulmonary Disease-Emphysema PathogenesisParkin-mediated ubiquitin signalling in aggresome formation and autophagy.High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4.Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTSGenetic control of weight loss during pneumonic Burkholderia pseudomallei infection.The ubiquitin-proteasome pathway and synaptic plasticity.Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implicationsCellular strategies for controlling protein aggregation.Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking.Neddylation dysfunction in Alzheimer's disease.Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy.Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease.Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.The Jak/STAT signaling pathway is downregulated at febrile temperatures.PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages.Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease.Versatile roles of k63-linked ubiquitin chains in trafficking.Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast.High-mobility group box 1 is essential for mitochondrial quality control.Disruption of protein quality control in Parkinson's disease.Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.Isolation of aggresomes and other large aggregatesAutophagy is involved in endogenous and NVP-AUY922-induced KIT degradation in gastrointestinal stromal tumors.Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
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Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 October 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Parkin-mediated K63-linked pol ...... e aggresome-autophagy pathway.
@en
Parkin-mediated K63-linked pol ...... e aggresome-autophagy pathway.
@nl
type
label
Parkin-mediated K63-linked pol ...... e aggresome-autophagy pathway.
@en
Parkin-mediated K63-linked pol ...... e aggresome-autophagy pathway.
@nl
prefLabel
Parkin-mediated K63-linked pol ...... e aggresome-autophagy pathway.
@en
Parkin-mediated K63-linked pol ...... e aggresome-autophagy pathway.
@nl
P2860
P356
P1433
P1476
Parkin-mediated K63-linked pol ...... he aggresome-autophagy pathway
@en
P2093
Lih-Shen Chin
P2860
P356
10.4161/AUTO.5172
P577
2007-10-15T00:00:00Z