Precision-cut tissue slices as a tool to predict metabolism of novel drugs.
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Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices.Laser microdissection of the alveolar duct enables single-cell genomic analysis.From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitationsCardiac tissue slices: preparation, handling, and successful optical mapping.Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease researchMurine Short Axis Ventricular Heart Slices for Electrophysiological Studies.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Microfluidic devices for in vitro studies on liver drug metabolism and toxicity.Artificial airways for the study of respiratory disease.Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results.Use of precision-cut renal cortical slices in nephrotoxicity studies.Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies.Assessment of immunotoxicity using precision-cut tissue slices.An evaluation of the latest in vitro tools for drug metabolism studies.Development of novel tools for the in vitro investigation of drug-induced liver injury.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo.Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools.Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.Differential expression of pathogenic genes of Entamoeba histolytica vs E. dispar in a model of infection using human liver tissue explants.Precision-cut rat, mouse, and human intestinal slices as novel models for the early-onset of intestinal fibrosisVitamin C acts as a hepatoprotectant in carbofuran treated rat liver slices in vitro.Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate.Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system.Non-alcoholic fatty liver disease (NAFLD) models in drug discovery.Assessment of liver slices for research on metabolic drug-drug interactions in cattle.Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR.On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent.Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study.Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity
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P2860
Precision-cut tissue slices as a tool to predict metabolism of novel drugs.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2007
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Precision-cut tissue slices as a tool to predict metabolism of novel drugs.
@en
Precision-cut tissue slices as a tool to predict metabolism of novel drugs.
@nl
type
label
Precision-cut tissue slices as a tool to predict metabolism of novel drugs.
@en
Precision-cut tissue slices as a tool to predict metabolism of novel drugs.
@nl
prefLabel
Precision-cut tissue slices as a tool to predict metabolism of novel drugs.
@en
Precision-cut tissue slices as a tool to predict metabolism of novel drugs.
@nl
P356
P1476
Precision-cut tissue slices as a tool to predict metabolism of novel drugs
@en
P2093
Geny Mm Groothuis
Inge Am de Graaf
P304
P356
10.1517/17425255.3.6.879
P407
P50
P577
2007-12-01T00:00:00Z