Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancer.
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Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseMitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer ChemotherapyHuman mitochondrial transcription factor A induces a U-turn structure in the light strand promoterMitochondrial genomic variation associated with higher mitochondrial copy number: the Cache County Study on Memory Health and AgingThe Roles of Mitochondrial Damage-Associated Molecular Patterns in DiseasesComprehensive assessment of cancer missense mutation clustering in protein structuresMitochondria and cancerAcetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis.Expression of mitochondrial regulators PGC1α and TFAM as putative markers of subtype and chemoresistance in epithelial ovarian carcinomaIdentification of speckle-type POZ protein somatic mutations in African American prostate cancer.Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast.The "fast" and the "slow" modes of mitochondrial DNA degradation.Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connectionInactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis.Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs.Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo.Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells.Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma.Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics.Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin-Two Main Metabolites of Curcuma longa-in Cancer Cells.p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancerKIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancerComplex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression.Spotlight on the relevance of mtDNA in cancer.Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection.Mitochondrial determinants of cancer health disparities.Detection of DNA repair protein in colorectal cancer of patients up to 50 years old can increase the identification of Lynch syndrome?Mitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis.Roles of mitochondrial transcription factor A and microRNA-590-3p in the development of bladder cancer.The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities.Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 predicts a poor clinical outcome of breast cancer.Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer.TFAM is required for maturation of the fetal and adult intestinal epithelium.ONC201 kills breast cancer cells in vitro by targeting mitochondria.
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P2860
Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancer.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 April 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Frequent truncating mutation o ...... te-unstable colorectal cancer.
@en
Frequent truncating mutation o ...... te-unstable colorectal cancer.
@nl
type
label
Frequent truncating mutation o ...... te-unstable colorectal cancer.
@en
Frequent truncating mutation o ...... te-unstable colorectal cancer.
@nl
prefLabel
Frequent truncating mutation o ...... te-unstable colorectal cancer.
@en
Frequent truncating mutation o ...... te-unstable colorectal cancer.
@nl
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P2860
P921
P1433
P1476
Frequent truncating mutation o ...... te-unstable colorectal cancer.
@en
P2093
Amy J French
Dongchon Kang
Jianhui Guo
Stephen N Thibodeau
Wanguo Liu
Wenyong Liu
Zehua Wang
Zemin Wang
P2860
P304
P356
10.1158/0008-5472.CAN-10-3482
P407
P50
P577
2011-04-05T00:00:00Z