Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors. - Wikidata - awgldk - TriplyDB

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

http://www.wikidata.org/entity/Q37011768

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Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents Predicting mTOR inhibitors with a classifier using recursive partitioning and Naïve Bayesian approaches Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail.Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity.β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays.Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling.Quinazoline derivatives as anticancer drugs: a patent review (2011 - present).Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents.The collective nuclear migration of p53 and phosphorylated S473 of Akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells.The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling.Rhodium-Catalyzed Asymmetric N-H Functionalization of Quinazolinones with Allenes and Allylic Carbonates: The First Enantioselective Formal Total Synthesis of (-)-Chaetominine.Proposed Molecular and miRNA Classification of Gastric Cancer.

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Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

http://www.wikidata.org/entity/Q37011768

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 09 May 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

@en

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

@nl

type

label

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

@en

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

@nl

prefLabel

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

@en

Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

@nl

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J.BMC.2013.04.083

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Bioorganic & Medicinal Chemistry

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Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors.

@en

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George Kulik

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Mark E Welker

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P2860

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Design of selective, ATP-competitive inhibitors of Akt

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799

Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors

Discovery of triazine-benzimidazoles as selective inhibitors of mTOR

Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives

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4063-4091

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scholarly article

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10.1016/J.BMC.2013.04.083

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2013-05-09T00:00:00Z

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23735831

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3711139

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