A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
about
Protease resistant protein cellular isoform (PrP(c)) as a biomarker: clues into the pathogenesis of HANDActivation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in malesKallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity.Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity.A C-terminal membrane anchor affects the interactions of prion proteins with lipid membranes.The elusive role of the prion protein and the mechanism of toxicity in prion disease.A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein.Exploring the cause of initially reactive bovine brains on rapid tests for BSE.Synaptic dysfunction in prion diseases: a trafficking problem?The prion protein family member Shadoo induces spontaneous ionic currents in cultured cells.Polyphenols: multipotent therapeutic agents in neurodegenerative diseases.An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.Identification of Anti-prion Compounds using a Novel Cellular Assay.Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice.Common themes in PrP signaling: the Src remains the same.
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P2860
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2013
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
@en
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.
@nl
type
label
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
@en
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.
@nl
prefLabel
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
@en
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.
@nl
P2093
P2860
P50
P1476
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity
@en
P2093
Assunta Senatore
Hejiao Bian
Isaac H Solomon
Paul Toselli
Tania Massignan
Till Voigtlaender
Ursula Unterberger
P2860
P304
P356
10.1523/JNEUROSCI.3406-12.2013
P407
P577
2013-02-01T00:00:00Z